Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL050790-04
Application #
2227096
Study Section
Special Emphasis Panel (ZHL1-CSR-K (S2))
Project Start
1993-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Blank, M; Eldor, A; Tavor, S et al. (1999) A mouse model for heparin-induced thrombocytopenia. Semin Hematol 36:12-6
Cines, D B (1998) Glycoprotein IIb/IIIa antagonists: potential induction and detection of drug-dependent antiplatelet antibodies. Am Heart J 135:S152-9
Blank, M; Cines, D B; Arepally, G et al. (1997) Pathogenicity of human anti-platelet factor 4 (PF4)/heparin in vivo: generation of mouse anti-PF4/heparin and induction of thrombocytopenia by heparin. Clin Exp Immunol 108:333-9
Zhang, L; Strickland, D K; Cines, D B et al. (1997) Regulation of single chain urokinase binding, internalization, and degradation by a plasminogen activator inhibitor 1-derived peptide. J Biol Chem 272:27053-7
Arepally, G; McKenzie, S E; Jiang, X M et al. (1997) Fc gamma RIIA H/R 131 polymorphism, subclass-specific IgG anti-heparin/platelet factor 4 antibodies and clinical course in patients with heparin-induced thrombocytopenia and thrombosis. Blood 89:370-5
Shlansky-Goldberg, R D; Cines, D B; Sehgal, C M (1996) Catheter-delivered ultrasound potentiates in vitro thrombolysis. J Vasc Interv Radiol 7:313-20
Higazi, A A; Kniss, D; Manuppello, J et al. (1996) Thermotaxis of human trophoblastic cells. Placenta 17:683-7
Cines, D B; McCrae, K R (1995) The antiphospholipid-protein syndrome. J Clin Immunol 15:86S-100S
Arepally, G; Reynolds, C; Tomaski, A et al. (1995) Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. Am J Clin Pathol 104:648-54
Hasan, A A; Cines, D B; Herwald, H et al. (1995) Mapping the cell binding site on high molecular weight kininogen domain 5. J Biol Chem 270:19256-61