Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL051050-03
Application #
2227441
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
New York Blood Center
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10065
Mosesson, M W; DiOrio, J P; Hernandez, I et al. (2004) The ultrastructure of fibrinogen-420 and the fibrin-420 clot. Biophys Chem 112:209-14
Lishko, V K; Yakubenko, V P; Hertzberg, K M et al. (2001) The alternatively spliced alpha(E)C domain of human fibrinogen-420 is a novel ligand for leukocyte integrins alpha(M)beta(2) and alpha(X)beta(2). Blood 98:2448-55
Applegate, D; Steben, L S; Hertzberg, K M et al. (2000) The alpha(E)C domain of human fibrinogen-420 is a stable and early plasmin cleavage product. Blood 95:2297-303
Spraggon, G; Applegate, D; Everse, S J et al. (1998) Crystal structure of a recombinant alphaEC domain from human fibrinogen-420. Proc Natl Acad Sci U S A 95:9099-104
Fu, Y; Zhang, J Z; Redman, C M et al. (1998) Formation of the human fibrinogen subclass fib420: disulfide bonds and glycosylation in its unique (alphaE chain) domains. Blood 92:3302-8
Applegate, D; Haraga, L; Hertzberg, K M et al. (1998) The EC domains of human fibrinogen420 contain calcium binding sites but lack polymerization pockets. Blood 92:3669-74
Grieninger, G; Lu, X; Cao, Y et al. (1997) Fib420, the novel fibrinogen subclass: newborn levels are higher than adult. Blood 90:2609-14
Fu, Y; Cao, Y; Hertzberg, K M et al. (1995) Fibrinogen alpha genes: conservation of bipartite transcripts and carboxy-terminal-extended alpha subunits in vertebrates. Genomics 30:71-6