Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL051184-02
Application #
2227765
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1994-04-09
Project End
1995-07-31
Budget Start
1995-04-01
Budget End
1995-07-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Surgery
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Chang, David S; Su, Hua; Tang, Gale L et al. (2003) Adeno-associated viral vector-mediated gene transfer of VEGF normalizes skeletal muscle oxygen tension and induces arteriogenesis in ischemic rat hindlimb. Mol Ther 7:44-51
Brevetti, Lucy S; Chang, David S; Tang, Gale L et al. (2003) Overexpression of endothelial nitric oxide synthase increases skeletal muscle blood flow and oxygenation in severe rat hind limb ischemia. J Vasc Surg 38:820-6
Messina, Louis M; Brevetti, Lucy S; Chang, David S et al. (2002) Therapeutic angiogenesis for critical limb ischemia: invited commentary. J Control Release 78:285-94
Paek, Robert; Chang, David S; Brevetti, Lucy S et al. (2002) Correlation of a simple direct measurement of muscle pO(2) to a clinical ischemia index and histology in a rat model of chronic severe hindlimb ischemia. J Vasc Surg 36:172-9
Brevetti, Lucy S; Chang, David S; Sarkar, Rajabrata et al. (2002) Effect of adenoviral titer and instillation pressure on gene transfer efficiency to arterial and venous grafts ex-vivo. J Vasc Surg 36:263-70
Brevetti, L S; Paek, R; Brady, S E et al. (2001) Exercise-induced hyperemia unmasks regional blood flow deficit in experimental hindlimb ischemia. J Surg Res 98:21-6
Brevetti, L S; Sarkar, R; Chang, D S et al. (2001) Administration of adenoviral vectors induces gangrene in acutely ischemic rat hindlimbs: role of capsid protein-induced inflammation. J Vasc Surg 34:489-96
Furukawa, L; Brevetti, L S; Brady, S E et al. (2000) Adenoviral-mediated gene transfer of ICP47 inhibits major histocompatibility complex class I expression on vascular cells in vitro. J Vasc Surg 31:558-66
Zelenock, J A; Welling, T H; Sarkar, R et al. (1997) Improved retroviral transduction efficiency of vascular cells in vitro and in vivo during clinically relevant incubation periods using centrifugation to increase viral titers. J Vasc Surg 26:119-27
Ford, J W; Welling 3rd, T H; Stanley, J C et al. (1996) PKH26 and 125I-PKH95: characterization and efficacy as labels for in vitro and in vivo endothelial cell localization and tracking. J Surg Res 62:23-8

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