Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL051388-02
Application #
2228105
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1995-09-30
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Cleaves, Rebecca; Wang, Qian-fei; Friedman, Alan D (2004) C/EBPalphap30, a myeloid leukemia oncoprotein, limits G-CSF receptor expression but not terminal granulopoiesis via site-selective inhibition of C/EBP DNA binding. Oncogene 23:716-25
Yang, Yandan; Wang, Weihua; Cleaves, Rebecca et al. (2002) Acceleration of G(1) cooperates with core binding factor beta-smooth muscle myosin heavy chain to induce acute leukemia in mice. Cancer Res 62:2232-5
Bernardin, Florence; Yang, Yandan; Civin, Curt I et al. (2002) c-Myc overcomes cell cycle inhibition by CBFbeta-SMMHC, a myeloid leukemia oncoprotein. Cancer Biol Ther 1:492-6
Bernardin, Florence; Yang, Yandan; Cleaves, Rebecca et al. (2002) TEL-AML1, expressed from t(12;21) in human acute lymphocytic leukemia, induces acute leukemia in mice. Cancer Res 62:3904-8
Lou, J; Cao, W; Bernardin, F et al. (2000) Exogenous cdk4 overcomes reduced cdk4 RNA and inhibition of G1 progression in hematopoietic cells expressing a dominant-negative CBF - a model for overcoming inhibition of proliferation by CBF oncoproteins. Oncogene 19:2695-703
Nuchprayoon, I; Shang, J; Simkevich, C P et al. (1999) An enhancer located between the neutrophil elastase and proteinase 3 promoters is activated by Sp1 and an Ets factor. J Biol Chem 274:1085-91
Friedman, A D (1999) Leukemogenesis by CBF oncoproteins. Leukemia 13:1932-42
Britos-Bray, M; Ramirez, M; Cao, W et al. (1998) CBFbeta-SMMHC, expressed in M4eo acute myeloid leukemia, reduces p53 induction and slows apoptosis in hematopoietic cells exposed to DNA-damaging agents. Blood 92:4344-52
Cao, W; Adya, N; Britos-Bray, M et al. (1998) The core binding factor (CBF) alpha interaction domain and the smooth muscle myosin heavy chain (SMMHC) segment of CBFbeta-SMMHC are both required to slow cell proliferation. J Biol Chem 273:31534-40
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