Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL051399-02
Application #
2228124
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1995-05-01
Project End
2000-04-30
Budget Start
1996-01-01
Budget End
1996-04-30
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Fuentes-Prior, Pablo; Salvesen, Guy S (2004) The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J 384:201-32
Boatright, Kelly M; Salvesen, Guy S (2003) Caspase activation. Biochem Soc Symp :233-42
Boatright, Kelly M; Salvesen, Guy S (2003) Mechanisms of caspase activation. Curr Opin Cell Biol 15:725-31
Turk, Boris; Turk, Dusan; Salvesen, Guy S (2002) Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators. Curr Pharm Des 8:1623-37
Stennicke, Henning R; Ryan, Ciara A; Salvesen, Guy S (2002) Reprieval from execution: the molecular basis of caspase inhibition. Trends Biochem Sci 27:94-101
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Snipas, S J; Stennicke, H R; Riedl, S et al. (2001) Inhibition of distant caspase homologues by natural caspase inhibitors. Biochem J 357:575-80
Renatus, M; Zhou, Q; Stennicke, H R et al. (2000) Crystal structure of the apoptotic suppressor CrmA in its cleaved form. Structure 8:789-97
Deveraux, Q L; Stennicke, H R; Salvesen, G S et al. (1999) Endogenous inhibitors of caspases. J Clin Immunol 19:388-98
Stennicke, H R; Jurgensmeier, J M; Shin, H et al. (1998) Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem 273:27084-90

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