The focus of this study is on the relationship between lipoprotein metabolism, hypertension, and hyperinsulinemia-insulin resistance in African American males and females. Two populations are available for study - a younger cohort of hypertensives who have been followed for a number of years as part of the Philadelphia Collaborative Perinatal Project and an older group of veterans at the Philadelphia VA Medical Center. In a sub-set of these subjects with either high or low plasma insulin levels after a glucose challenge (insulin sensitive or insulin resistant), we will determine the fractional and absolute synthesis and catabolic rates of apolipoproteins B and A-I, the dominant apoproteins of Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). We will use stable isotopes and multicompartmental kinetic analysis following an oral bolus dose of deuteroleucine, using gas chromatography- mass spectrometry analytical techniques. Our working hypothesis is that in hypertensive African Americans with hyperinsulinemia, more of the smaller Very Low Density (VLDL) particles are secreted and converted to LDL.
| Sumner, A E; Falkner, B; Diffenderfer, M R et al. (1999) A study of the metabolism of apolipoprotein B100 in relation to insulin resistance in African American males. Proc Soc Exp Biol Med 221:352-60 |
| Sumner, A E; Kushner, H; Sherif, K D et al. (1999) Sex differences in African-Americans regarding sensitivity to insulin's glucoregulatory and antilipolytic actions. Diabetes Care 22:71-7 |
| Sumner, A E; Kushner, H; Tulenko, T N et al. (1997) The relationship in African-Americans of sex differences in insulin-mediated suppression of nonesterified fatty acids to sex differences in fasting triglyceride levels. Metabolism 46:400-5 |
| Sumner, A E; Kushner, H; Lakota, C A et al. (1996) Gender differences in insulin-induced free fatty acid suppression: studies in an African American population. Lipids 31 Suppl:S275-8 |
