Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL051588-03
Application #
2228448
Study Section
Special Emphasis Panel (ZHL1-CSR-S (S1))
Project Start
1993-12-15
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
J. David Gladstone Institutes
Department
Type
DUNS #
047120084
City
San Francisco
State
CA
Country
United States
Zip Code
94158
Rizzo, Manfredi; Taylor, John M; Barbagallo, Carlo M et al. (2004) Effects on lipoprotein subclasses of combined expression of human hepatic lipase and human apoB in transgenic rabbits. Arterioscler Thromb Vasc Biol 24:141-6
Barbagallo, C M; Fan, J; Blanche, P J et al. (1999) Overexpression of human hepatic lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions. Arterioscler Thromb Vasc Biol 19:625-32
Huang, Y; Ji, Z S; Brecht, W J et al. (1999) Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis. Arterioscler Thromb Vasc Biol 19:2952-9
Fan, J; Ji, Z S; Huang, Y et al. (1998) Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma. J Clin Invest 101:2151-64
Dichek, H L; Brecht, W; Fan, J et al. (1998) Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. J Biol Chem 273:1896-903
Taylor, J M; Fan, J (1997) Transgenic rabbit models for the study of atherosclerosis. Front Biosci 2:d298-308
Sanan, D A; Fan, J; Bensadoun, A et al. (1997) Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver. J Lipid Res 38:1002-13
Fan, J; McCormick, S P; Krauss, R M et al. (1995) Overexpression of human apolipoprotein B-100 in transgenic rabbits results in increased levels of LDL and decreased levels of HDL. Arterioscler Thromb Vasc Biol 15:1889-99
Fan, J; Wang, J; Bensadoun, A et al. (1994) Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc Natl Acad Sci U S A 91:8724-8