Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052012-02
Application #
2229111
Study Section
Metabolism Study Section (MET)
Project Start
1995-07-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Podrez, E A; O'Neil, J; Salomon, R G et al. (1998) Measurement of oxidation in plasma Lp(a) in CAPD patients using a novel ELISA. Kidney Int 54:637-45
Salomon, R G; Subbanagounder, G; O'Neil, J et al. (1997) Levuglandin E2-protein adducts in human plasma and vasculature. Chem Res Toxicol 10:536-45
Hoppe, G; Subbanagounder, G; O'Neil, J et al. (1997) Macrophage recognition of LDL modified by levuglandin E2, an oxidation product of arachidonic acid. Biochim Biophys Acta 1344:1-5
Salomon, R G; Subbanagounder, G; Singh, U et al. (1997) Oxidation of low-density lipoproteins produces levuglandin-protein adducts. Chem Res Toxicol 10:750-9
O'Neil, J; Hoppe, G; Sayre, L M et al. (1997) Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzyme. Free Radic Biol Med 23:215-25
Kaur, K; Salomon, R G; O'Neil, J et al. (1997) (Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins. Chem Res Toxicol 10:1387-96
Hoppe, G; Ravandi, A; Herrera, D et al. (1997) Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions. J Lipid Res 38:1347-60
Hoppe, G; O'Neil, J; Sayre, L M et al. (1997) Non-conventional modification of low density lipoproteins: chemical models for macrophage recognition of oxidized LDL. Biochim Biophys Acta 1362:103-8
Smejkal, G B; Hoppe, G; Hoff, H F (1996) Filipin as a fluorescent probe of lipoprotein-derived sterols on thin-layer chromatograms. Anal Biochem 239:115-7