Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052069-02
Application #
2229208
Study Section
Metabolism Study Section (MET)
Project Start
1995-07-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Dubrac, Sandrine; Lear, Steven R; Ananthanarayanan, Meena et al. (2005) Role of CYP27A in cholesterol and bile acid metabolism. J Lipid Res 46:76-85
Shenoy, Sarita D; Spencer, Thomas A; Mercer-Haines, Nancy A et al. (2004) CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor. Drug Metab Dispos 32:66-71
Shenoy, Sarita D; Spencer, Thomas A; Mercer-Haines, Nancy A et al. (2004) Induction of CYP3A by 2,3-oxidosqualene:lanosterol cyclase inhibitors is mediated by an endogenous squalene metabolite in primary cultured rat hepatocytes. Mol Pharmacol 65:1302-12
Erickson, Sandra K; Lear, Steven R; Deane, Sean et al. (2003) Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice. J Lipid Res 44:1001-9
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Li, D; Spencer, T A (2000) Synthesis of 7alpha-hydroxy derivatives of regulatory oxysterols. Steroids 65:529-35
Spencer, T A; Li, D; Russel, J S et al. (2000) Further studies on the synthesis of 24(S),25-epoxycholesterol. A new, efficient preparation of desmosterol. J Org Chem 65:1919-23
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