Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052282-03
Application #
2229583
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1994-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Murrell, Julie R; Randall, Jeffrey D; Rosoff, James et al. (2005) Endogenous ouabain: upregulation of steroidogenic genes in hypertensive hypothalamus but not adrenal. Circulation 112:1301-8
Parhami-Seren, Behnaz; Krudysz, Jolanta; Tsantili, Panayota (2002) Affinity panning of peptide libraries using anti-streptokinase monoclonal antibodies: selection of an inhibitor of plasmin(ogen) active site. J Immunol Methods 267:185-98
Parhami-Seren, Behnaz; Viswanathan, Malini; Margolies, Michael N (2002) Selection of high affinity p-azophenyarsonate Fabs from heavy-chain CDR2 insertion libraries. J Immunol Methods 259:43-53
Parhami-Seren, Behnaz; Haberly, Richard; Margolies, Michael N et al. (2002) Ouabain-binding protein(s) from human plasma. Hypertension 40:220-8
Kawamura, A; Abrell, L M; Maggiali, F et al. (2001) Biological implication of conformational flexibility in ouabain: observations with two ouabain phosphate isomers. Biochemistry 40:5835-44
Parhami-Seren, B; Viswanathan, M; Strong, R K et al. (2001) Structural analysis of mutants of high-affinity and low-affinity p-azophenylarsonate-specific antibodies generated by alanine scanning of heavy chain complementarity-determining region 2. J Immunol 167:5129-35
Dong, J G; Guo, J; Akritopoulou-Zanze, I et al. (1999) Theoretical and experimental CD of conformationally flexible complex molecules-application to ouabain pentanaphthoate and analogs. Chirality 11:707-21
Parhami-Seren, B; Bell, C; Margolies, M N et al. (1999) Monoclonal antibodies that distinguish between two related digitalis glycosides, ouabain and digoxin. J Immunol 163:4360-6
Kawamura, A; Guo, J; Itagaki, Y et al. (1999) On the structure of endogenous ouabain. Proc Natl Acad Sci U S A 96:6654-9
De Angelis, C; Haupert Jr, G T (1998) Hypoxia triggers release of an endogenous inhibitor of Na(+)-K(+)-ATPase from midbrain and adrenal. Am J Physiol 274:F182-8

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