Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052475-03
Application #
2229859
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Beck, Z Q; Hervio, L; Dawson, P E et al. (2000) Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development. Virology 274:391-401
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Coombs, G S; Rao, M S; Olson, A J et al. (1999) Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains. J Biol Chem 274:24074-9
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Coombs, G S; Bergstrom, R C; Madison, E L et al. (1998) Directing sequence-specific proteolysis to new targets. The influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and urokinase-type plasminogen activator. J Biol Chem 273:4323-8
Coombs, G S; Bergstrom, R C; Pellequer, J L et al. (1998) Substrate specificity of prostate-specific antigen (PSA). Chem Biol 5:475-88
Ke, S H; Coombs, G S; Tachias, K et al. (1997) Optimal subsite occupancy and design of a selective inhibitor of urokinase. J Biol Chem 272:20456-62
Tachias, K; Madison, E L (1997) Converting tissue type plasminogen activator into a zymogen. Important role of Lys156. J Biol Chem 272:28-31
Ke, S H; Tachias, K; Lamba, D et al. (1997) Identification of a hydrophobic exosite on tissue type plasminogen activator that modulates specificity for plasminogen. J Biol Chem 272:1811-6
Ke, S H; Coombs, G S; Tachias, K et al. (1997) Distinguishing the specificities of closely related proteases. Role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase. J Biol Chem 272:16603-9

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