Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL052492-01A2
Application #
2229886
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1996-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oak Ridge Associated Universities
Department
Type
DUNS #
City
Oak Ridge
State
TN
Country
United States
Zip Code
37831
Lee, T; Malone, B; Longobardi, L et al. (2001) Differential regulation of three catalytic activities of platelet-activating factor (PAF)-dependent transacetylase. Arch Biochem Biophys 387:41-6
Lee, T C (2000) N-acetylation of sphingosine by platelet-activating factor: sphingosine transacetylase. Methods Enzymol 311:117-22
Bae, K; Longobardi, L; Karasawa, K et al. (2000) Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF acetylhydrolases. J Biol Chem 275:26704-9
Balestrieri, M L; Lee, T (2000) Regulation of the biosynthesis of acyl analogs of platelet-activating factor by purinergic agonist in endothlial cells. FEBS Lett 479:63-6
Karasawa, K; Qiu, X; Lee, T (1999) Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide. J Biol Chem 274:8655-61
Lee, T C (1998) Biosynthesis and possible biological functions of plasmalogens. Biochim Biophys Acta 1394:129-45
Balestrieri, M L; Malik, K U; Balestrieri, C et al. (1998) Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. Prostaglandins Other Lipid Mediat 56:363-75
Balestrieri, M L; Servillo, L; Lee, T (1997) The role of platelet-activating factor-dependent transacetylase in the biosynthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine by stimulated endothelial cells. J Biol Chem 272:17431-7