Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052766-03
Application #
2230360
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1994-09-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Oh, Phil; Horner, Thierry; Witkiewicz, Halina et al. (2012) Endothelin induces rapid, dynamin-mediated budding of endothelial caveolae rich in ET-B. J Biol Chem 287:17353-62
Massey, Kerri A; Schnitzer, Jan E (2009) Targeting and imaging signature caveolar molecules in lungs. Proc Am Thorac Soc 6:419-30
Testa, Jacqueline E; Chrastina, Adrian; Li, Yan et al. (2009) Ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat. J Vasc Res 46:311-24
Testa, Jacqueline E; Chrastina, Adrian; Oh, Phil et al. (2009) Immunotargeting and cloning of two CD34 variants exhibiting restricted expression in adult rat endothelia in vivo. Am J Physiol Lung Cell Mol Physiol 297:L251-62
Oh, Phil; Borgstrom, Per; Witkiewicz, Halina et al. (2007) Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung. Nat Biotechnol 25:327-37
Durr, Eberhard; Yu, Jingyi; Krasinska, Karolina M et al. (2004) Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture. Nat Biotechnol 22:985-92
McIntosh, Deirdre P; Tan, Xiang-Yang; Oh, Phil et al. (2002) Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery. Proc Natl Acad Sci U S A 99:1996-2001
Oh, P; Schnitzer, J E (2001) Segregation of heterotrimeric G proteins in cell surface microdomains. G(q) binds caveolin to concentrate in caveolae, whereas G(i) and G(s) target lipid rafts by default. Mol Biol Cell 12:685-98
Schnitzer, J E (2001) Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivo. Adv Drug Deliv Rev 49:265-80
Oh, P; Schnitzer, J E (1999) Immunoisolation of caveolae with high affinity antibody binding to the oligomeric caveolin cage. Toward understanding the basis of purification. J Biol Chem 274:23144-54

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