Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053080-03
Application #
2230841
Study Section
Special Emphasis Panel (ZHL1-CSR-N (S1))
Project Start
1994-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Boston University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Sun, S; Jackson, C W; Ravid, K (2000) MAP kinase localizes to the platelet-yielding demarcation membrane system in megakaryocytes. Blood 95:1511
Zimmet, J; Ravid, K (2000) Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system. Exp Hematol 28:16-Mar
Cataldo, L M; Zhang, Y; Lu, J et al. (1999) Rat NAP1: cDNA cloning and upregulation by Mpl ligand. Gene 226:355-64
Wang, Z; Zhang, Y; Lu, J et al. (1999) Mpl ligand enhances the transcription of the cyclin D3 gene: a potential role for Sp1 transcription factor. Blood 93:4208-21
Sun, S; Ravid, K (1999) Role of a serine/threonine kinase, Mst1, in megakaryocyte differentiation. J Cell Biochem 76:44-60
Sun, S; Kaluzhny, Y; Ravid, K (1999) Ectopic expression of the Aspergillus nidulans mitotic inducer, nimA kinase, in megakaryocytes: effect on polyploidization. Exp Hematol 27:594-604
Zhang, Y; Wang, Z; Liu, D X et al. (1998) Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes. J Biol Chem 273:1387-92
Zimmet, J M; Toselli, P; Ravid, K (1998) Cyclin D3 and megakaryocyte development: exploration of a transgenic phenotype. Stem Cells 16 Suppl 2:97-106
Zimmet, J M; Ladd, D; Jackson, C W et al. (1997) A role for cyclin D3 in the endomitotic cell cycle. Mol Cell Biol 17:7248-59
Zhang, Y; Wang, Z; Ravid, K (1996) The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase. J Biol Chem 271:4266-72

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