This is a resubmitted grant application to study endothelium- dependent relaxation in the coronary circulation of patients with coronary atherosclerosis. The application emphasizes the relationship of abnormalities in redox state and the generation and release of EDRF in these patients. Endothelium-dependent vasomotion will be studied in response to infusions of acetylcholine and substance P and increased blood flow during cardiac pacing. Vasomotor responses will assessed using intracoronary Doppler and quantitative angiography. These responses will be related to markers of antioxidant protection and oxidative stress in the coronary vasculature (coronary sinus concentrations of F2-isoprostanes and endothelin) and the systemic circulation (plasma antioxidant content and LDL susceptibility to oxidation). To examine the contribution of superoxide production to abnormal coronary activity, vasomotor responses will be examined following treatment with specific inhibitors of superoxide action.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053398-05
Application #
6030688
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1995-07-01
Project End
2000-06-30
Budget Start
1999-07-01
Budget End
2000-06-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
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