Regulation of Na+/K+ Pump Current in the Heart

Mathias, Richard T.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL054031-02
• Application #: 2232215
• Study Section: Special Emphasis Panel (ZRG2-PHY (02))
• Project Start: 1995-05-01
• Project End: 2000-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: State University New York Stony Brook
• Department: Physiology
• Type: Schools of Medicine
• DUNS #: 804878247
• City: Stony Brook
• State: NY
• Country: United States
• Zip Code: 11794

Publications

Gao, J; Wang, W; Cohen, I S et al. (2005) Transmural gradients in Na/K pump activity and [Na+]I in canine ventricle. Biophys J 89:1700-9

Irie, Hiroshi; Gao, Junyuan; Gaudette, Glenn R et al. (2003) Both metabolic inhibition and mitochondrial K(ATP) channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current. Circulation 108 Suppl 1:II341-7

Gao, Junyuan; Wymore, Randy S; Wang, Yongli et al. (2002) Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides. J Gen Physiol 119:297-312

Gao, J; Sun, X; Yatsula, V et al. (2000) Isoform-specific function and distribution of Na/K pumps in the frog lens epithelium. J Membr Biol 178:89-101

Gao, J; Wymore, R; Wymore, R T et al. (1999) Isoform-specific regulation of the sodium pump by alpha- and beta-adrenergic agonists in the guinea-pig ventricle. J Physiol 516 ( Pt 2):377-83

Gao, J; Mathias, R T; Cohen, I S et al. (1999) Activation of PKC increases Na+-K+ pump current in ventricular myocytes from guinea pig heart. Pflugers Arch 437:643-51

Wang, Y; Gao, J; Mathias, R T et al. (1998) alpha-Adrenergic effects on Na+-K+ pump current in guinea-pig ventricular myocytes. J Physiol 509 ( Pt 1):117-28

Gao, J; Cohen, I S; Mathias, R T et al. (1998) The inhibitory effect of beta-stimulation on the Na/K pump current in guinea pig ventricular myocytes is mediated by a cAMP-dependent PKA pathway. Pflugers Arch 435:479-84

Gao, J; Mathias, R T; Cohen, I S et al. (1997) Effects of acetylcholine on the Na(+)-K+ pump current in guinea-pig ventricular myocytes. J Physiol 501 ( Pt 3):527-35

Gao, J; Mathias, R T; Cohen, I S et al. (1996) The effects of beta-stimulation on the Na(+)-K+ pump current-voltage relationship in guinea-pig ventricular myocytes. J Physiol 494 ( Pt 3):697-708