Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL054297-01A2
Application #
2232627
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1996-08-01
Project End
2000-06-30
Budget Start
1996-08-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Chattopadhyay, Saurabh; Karan, Goutam; Sen, Indira et al. (2008) A small region in the angiotensin-converting enzyme distal ectodomain is required for cleavage-secretion of the protein at the plasma membrane. Biochemistry 47:8335-41
Chattopadhyay, Saurabh; Santhamma, Kizhakkekara R; Sengupta, Saubhik et al. (2005) Calmodulin binds to the cytoplasmic domain of angiotensin-converting enzyme and regulates its phosphorylation and cleavage secretion. J Biol Chem 280:33847-55
Santhamma, Kizhakkekara R; Sadhukhan, Ramkrishna; Kinter, Michael et al. (2004) Role of tyrosine phosphorylation in the regulation of cleavage secretion of angiotensin-converting enzyme. J Biol Chem 279:40227-36
Santhamma, K R; Sen, I (2000) Specific cellular proteins associate with angiotensin-converting enzyme and regulate its intracellular transport and cleavage-secretion. J Biol Chem 275:23253-8
Sadhukhan, R; Santhamma, K R; Reddy, P et al. (1999) Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient mice. J Biol Chem 274:10511-6
Sadhukhan, R; Sen, G C; Ramchandran, R et al. (1998) The distal ectodomain of angiotensin-converting enzyme regulates its cleavage-secretion from the cell surface. Proc Natl Acad Sci U S A 95:138-43