Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL054329-05A1
Application #
6332144
Study Section
Physiological Chemistry Study Section (PC)
Program Officer
Lin, Michael
Project Start
1996-07-01
Project End
2006-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
5
Fiscal Year
2001
Total Cost
$296,000
Indirect Cost

  Institution

Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195

  Publications

Misono, Kunio S; Philo, John S; Arakawa, Tsutomu et al. (2011) Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase. FEBS J 278:1818-29
Ogawa, Haruo; Qiu, Yue; Philo, John S et al. (2010) Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: possible allosteric regulation and a conserved structural motif for the chloride-binding site. Protein Sci 19:544-57
Ogawa, Haruo; Qiu, Yue; Huang, Liming et al. (2009) Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy. FEBS J 276:1347-55
Misono, Kunio S; Ogawa, Haruo; Qiu, Yue et al. (2005) Structural studies of the natriuretic peptide receptor: a novel hormone-induced rotation mechanism for transmembrane signal transduction. Peptides 26:957-68
Qiu, Yue; Ogawa, Haruo; Miyagi, Masaru et al. (2004) Constitutive activation and uncoupling of the atrial natriuretic peptide receptor by mutations at the dimer interface. Role of the dimer structure in signalling. J Biol Chem 279:6115-23
Ogawa, Haruo; Qiu, Yue; Ogata, Craig M et al. (2004) Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction. J Biol Chem 279:28625-31
Ogawa, Haruo; Zhang, Xiaolun; Qiu, Yue et al. (2003) Crystallization and preliminary X-ray analysis of the atrial natriuretic peptide (ANP) receptor extracellular domain complex with ANP: use of ammonium sulfate as the cryosalt. Acta Crystallogr D Biol Crystallogr 59:1831-3
Miyagi, M; Zhang, X; Misono, K S (2000) Glycosylation sites in the atrial natriuretic peptide receptor: oligosaccharide structures are not required for hormone binding. Eur J Biochem 267:5758-68
Miyagi, M; Misono, K S (2000) Disulfide bond structure of the atrial natriuretic peptide receptor extracellular domain: conserved disulfide bonds among guanylate cyclase-coupled receptors. Biochim Biophys Acta 1478:30-8
Misono, K S (2000) Atrial natriuretic factor binding to its receptor is dependent on chloride concentration: A possible feedback-control mechanism in renal salt regulation. Circ Res 86:1135-9

Showing the most recent 10 out of 13 publications