Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL054568-03
Application #
2833219
Study Section
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Tyska, Matthew J; Warshaw, David M (2002) The myosin power stroke. Cell Motil Cytoskeleton 51:1-15
Rovner, Arthur S; Fagnant, Patricia M; Lowey, Susan et al. (2002) The carboxyl-terminal isoforms of smooth muscle myosin heavy chain determine thick filament assembly properties. J Cell Biol 156:113-23
Lauzon, A M; Fagnant, P M; Warshaw, D M et al. (2001) Coiled-coil unwinding at the smooth muscle myosin head-rod junction is required for optimal mechanical performance. Biophys J 80:1900-4
Joel, P B; Trybus, K M; Sweeney, H L (2001) Two conserved lysines at the 50/20-kDa junction of myosin are necessary for triggering actin activation. J Biol Chem 276:2998-3003
Yamashita, H; Tyska, M J; Warshaw, D M et al. (2000) Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy. J Biol Chem 275:28045-52
Warshaw, D M; Guilford, W H; Freyzon, Y et al. (2000) The light chain binding domain of expressed smooth muscle heavy meromyosin acts as a mechanical lever. J Biol Chem 275:37167-72
Tyska, M J; Dupuis, D E; Guilford, W H et al. (1999) Two heads of myosin are better than one for generating force and motion. Proc Natl Acad Sci U S A 96:4402-7
Lauzon, A M; Tyska, M J; Rovner, A S et al. (1998) A 7-amino-acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin in the laser trap. J Muscle Res Cell Motil 19:825-37
Bentil, D E (1998) Distribution of attachment events relative to actin binding sites as evidenced in a bidirectional actomyosin interaction model. Bull Math Biol 60:973-95
VanBuren, P; Begin, K; Warshaw, D M (1998) Fluorescent phalloidin enables visualization of actin without effects on myosin's actin filament sliding velocity and hydrolytic properties in vitro. J Mol Cell Cardiol 30:2777-83

Showing the most recent 10 out of 11 publications