Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL054578-01A1
Application #
2232956
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Project Start
1996-04-01
Project End
1999-02-28
Budget Start
1996-04-01
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Temple University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Knight, Linda C; Romano, Jan E; Bright, Lewis T et al. (2007) Platelet binding and biodistribution of [99mTc]rBitistatin in animal species and humans. Nucl Med Biol 34:855-63
Knight, Linda C; Romano, Jan E; Cosenza, Stephen C et al. (2007) Differences in binding of (99m)Tc-disintegrins to integrin alphavbeta3 on tumor and vascular cells. Nucl Med Biol 34:371-81
Knight, Linda C; Romano, Jan E (2005) Functional expression of bitistatin, a disintegrin with potential use in molecular imaging of thromboembolic disease. Protein Expr Purif 39:307-19
Baidoo, Kwamena E; Knight, Linda C; Lin, Kuo-Shyan et al. (2004) Design and synthesis of a short-chain bitistatin analogue for imaging thrombi and emboli. Bioconjug Chem 15:1068-75
McQuade, Paul; Knight, Linda C; Welch, Michael J (2004) Evaluation of 64Cu- and 125I-radiolabeled bitistatin as potential agents for targeting alpha v beta 3 integrins in tumor angiogenesis. Bioconjug Chem 15:988-96
Knight, L C (2003) Non-oncologic applications of radiolabeled peptides in nuclear medicine. Q J Nucl Med 47:279-91
Knight, L C; Baidoo, K E; Romano, J E et al. (2000) Imaging pulmonary emboli and deep venous thrombi with 99mTc-bitistatin, a platelet-binding polypeptide from viper venom. J Nucl Med 41:1056-64
Knight, L C; Romano, J E; Maurer, A H (1998) In vitro platelet binding compared with in vivo thrombus imaging using alpha(IIb)beta3-targeted radioligands. Thromb Haemost 80:845-51