Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054592-02
Application #
2029460
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1995-09-25
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Watson, Peter A; Birdsey, Nicholas; Huggins, Gordon S et al. (2010) Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice. Am J Physiol Heart Circ Physiol 299:H2056-68
Gupta, Amitabh; Hou, Rong; Liu, Liming et al. (2009) Daxx inhibits muscle differentiation by repressing E2A-mediated transcription. J Cell Biochem 107:438-47
Dean, Jarrod; Plante, Jeremy; Huggins, Gordon S et al. (2009) Role of cyclic AMP-dependent kinase response element-binding protein in recombinant adeno-associated virus-mediated transduction of heart muscle cells. Hum Gene Ther 20:1005-12
Aikawa, Ryuichi; Huggins, Gordon S; Snyder, Richard O (2002) Cardiomyocyte-specific gene expression following recombinant adeno-associated viral vector transduction. J Biol Chem 277:18979-85
Huggins, G S; Bacani, C J; Boltax, J et al. (2001) Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter. J Biol Chem 276:28029-36
Fentzke, R C; Korcarz, C E; Shroff, S G et al. (2001) The left ventricular stress-velocity relation in transgenic mice expressing a dominant negative CREB transgene in the heart. J Am Soc Echocardiogr 14:209-18
Svensson, E C; Huggins, G S; Dardik, F B et al. (2000) A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription. J Biol Chem 275:20762-9
Arteaga, G M; Palmiter, K A; Leiden, J M et al. (2000) Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I. J Physiol 526 Pt 3:541-9
Svensson, E C; Huggins, G S; Lin, H et al. (2000) A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet 25:353-6
Svensson, E C; Tufts, R L; Polk, C E et al. (1999) Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Proc Natl Acad Sci U S A 96:956-61

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