Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL054598-01A1
Application #
2232987
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1996-06-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Ma, Junfeng; Banerjee, Partha; Whelan, Stephen A et al. (2016) Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res 15:2254-64
Tocchetti, Carlo G; Stanley, Brian A; Sivakumaran, Vidhya et al. (2015) Impaired mitochondrial energy supply coupled to increased H2O2 emission under energy/redox stress leads to myocardial dysfunction during Type I diabetes. Clin Sci (Lond) 129:561-74
Zhou, Lufang; Aon, Miguel A; Almas, Tabish et al. (2010) A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network. PLoS Comput Biol 6:e1000657
Aon, Miguel Antonio; Cortassa, Sonia; Akar, Fadi Gabriel et al. (2006) Mitochondrial criticality: a new concept at the turning point of life or death. Biochim Biophys Acta 1762:232-40
Akar, Fadi G; Aon, Miguel A; Tomaselli, Gordon F et al. (2005) The mitochondrial origin of postischemic arrhythmias. J Clin Invest 115:3527-35
Cortassa, Sonia; Aon, Miguel A; Winslow, Raimond L et al. (2004) A mitochondrial oscillator dependent on reactive oxygen species. Biophys J 87:2060-73
O'Rourke, Brian (2004) Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res 94:420-32
Cortassa, Sonia; Aon, Miguel A; Marban, Eduardo et al. (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J 84:2734-55
Aon, Miguel A; Cortassa, Sonia; Marban, Eduardo et al. (2003) Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem 278:44735-44
Sasaki, N; Sato, T; Marban, E et al. (2001) ATP consumption by uncoupled mitochondria activates sarcolemmal K(ATP) channels in cardiac myocytes. Am J Physiol Heart Circ Physiol 280:H1882-8

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