Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054768-02
Application #
2233219
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Pharmacology
Type
Schools of Medicine
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Wolff, D J; Mialkowski, K; Richardson, C F et al. (2001) C60-Fullerene monomalonate adducts selectively inactivate neuronal nitric oxide synthase by uncoupling the formation of reactive oxygen intermediates from nitric oxide production. Biochemistry 40:37-45
Wolff, D J; Papoiu, A D; Mialkowski, K et al. (2000) Inhibition of nitric oxide synthase isoforms by tris-malonyl-C(60)-fullerene adducts. Arch Biochem Biophys 378:216-23
Cooper, G R; Mialkowski, K; Wolff, D J (2000) Cellular and enzymatic studies of N(omega)-propyl-l-arginine and S-ethyl-N-[4-(trifluoromethyl)phenyl]isothiourea as reversible, slowly dissociating inhibitors selective for the neuronal nitric oxide synthase isoform. Arch Biochem Biophys 375:183-94
Bryk, R; Lubeskie, A; Wolff, D J (1999) Studies of neuronal nitric oxide synthase inactivation by diverse suicide inhibitors. Arch Biochem Biophys 369:243-51
Bryk, R; Wolff, D J (1999) Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitors. Pharmacol Ther 84:157-78
Bryk, R; Wolff, D J (1998) Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine. Biochemistry 37:4844-52
Cooper, G R; Barr, A; Wolff, D J (1998) Neuronal nitric oxide synthase is refractory to mechanism-based inactivation in GH3 pituitary cells. Arch Biochem Biophys 357:195-206
Wolff, D J; Lubeskie, A; Gauld, D S et al. (1998) Inactivation of nitric oxide synthases and cellular nitric oxide formation by N6-iminoethyl-L-lysine and N5-iminoethyl-L-ornithine. Eur J Pharmacol 350:325-34
Wolff, D J; Gauld, D S; Neulander, M J et al. (1997) Inactivation of nitric oxide synthase by substituted aminoguanidines and aminoisothioureas. J Pharmacol Exp Ther 283:265-73
Wolff, D J; Lubeskie, A; Li, C (1997) Inactivation and recovery of nitric oxide synthetic capability in cytokine-induced RAW 264.7 cells treated with ""irreversible"" NO synthase inhibitors. Arch Biochem Biophys 338:73-82

Showing the most recent 10 out of 14 publications