Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054816-02
Application #
2233283
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Biederman, Robert W W; Young, Alistair A; Doyle, Mark et al. (2015) Regional Heterogeneity in 3D Myocardial Shortening in Hypertensive Left Ventricular Hypertrophy: A Cardiovascular CMR Tagging Substudy to the Life Study. J Biomed Sci Eng 8:213-225
Gladden, James D; Zelickson, Blake R; Guichard, Jason L et al. (2013) Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload. Am J Physiol Heart Circ Physiol 305:H1440-50
Chen, Yuan-Wen; Pat, Betty; Gladden, James D et al. (2011) Dynamic molecular and histopathological changes in the extracellular matrix and inflammation in the transition to heart failure in isolated volume overload. Am J Physiol Heart Circ Physiol 300:H2251-60
Ulasova, Elena; Gladden, James D; Chen, Yuanwen et al. (2011) Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload. J Mol Cell Cardiol 50:147-56
Gladden, James D; Zelickson, Blake R; Wei, Chih-Chang et al. (2011) Novel insights into interactions between mitochondria and xanthine oxidase in acute cardiac volume overload. Free Radic Biol Med 51:1975-84
Chen, Yuanwen; Pat, Betty; Zheng, Junying et al. (2010) Tumor necrosis factor-alpha produced in cardiomyocytes mediates a predominant myocardial inflammatory response to stretch in early volume overload. J Mol Cell Cardiol 49:70-8
Wei, Chih-Chang; Hase, Naoki; Inoue, Yukiko et al. (2010) Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest 120:1229-39
Ahmed, Mustafa I; McGiffin, David C; O'Rourke, Robert A et al. (2009) Mitral regurgitation. Curr Probl Cardiol 34:93-136
Biederman, Robert W W; Doyle, Mark; Young, Alistair A et al. (2008) Marked regional left ventricular heterogeneity in hypertensive left ventricular hypertrophy patients: a losartan intervention for endpoint reduction in hypertension (LIFE) cardiovascular magnetic resonance and echocardiographic substudy. Hypertension 52:279-86
Pat, Betty; Killingsworth, Cheryl; Denney, Thomas et al. (2008) Dissociation between cardiomyocyte function and remodeling with beta-adrenergic receptor blockade in isolated canine mitral regurgitation. Am J Physiol Heart Circ Physiol 295:H2321-7

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