Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL055401-01A1
Application #
2233977
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Narrows Institute for Biomedical Research Inc
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
11209
Yue, Yuankun; Qu, Yongxia; Boutjdir, Mohamed (2004) Beta- and alpha-adrenergic cross-signaling for L-type Ca current is impaired in transgenic mice with constitutive activation of epsilonPKC. Biochem Biophys Res Commun 314:749-54
Hu, Keli; Qu, Yongxia; Yue, Yuankun et al. (2004) Functional basis of sinus bradycardia in congenital heart block. Circ Res 94:e32-8
Xiao, Guang-Qian; Mochly-Rosen, Daria; Boutjdir, Mohamed (2003) PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current. Biochem Biophys Res Commun 306:1019-25
Buyon, Jill P; Clancy, Robert; Di Donato, Francis et al. (2002) Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block. J Autoimmun 19:79-86
Qu, Y; Xiao, G Q; Chen, L et al. (2001) Autoantibodies from mothers of children with congenital heart block downregulate cardiac L-type Ca channels. J Mol Cell Cardiol 33:1153-63
Xiao, G Q; Hu, K; Boutjdir, M (2001) Direct inhibition of expressed cardiac l- and t-type calcium channels by igg from mothers whose children have congenital heart block. Circulation 103:1599-604
Xiao, G Q; Qu, Y; Sun, Z Q et al. (2001) Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channels. Am J Physiol Cell Physiol 281:C1477-86
Restivo, M; Kozhevnikov, D O; Boutjdir, M (2001) Optical mapping of activation patterns in an animal model of congenital heart block. Am J Physiol Heart Circ Physiol 280:H1889-95
Qu, Y; Boutjdir, M (2001) Gene expression of SERCA2a and L- and T-type Ca channels during human heart development. Pediatr Res 50:569-74
Xiao, G Q; Qu, Y; Hu, K et al. (2001) Down-regulation of L-type calcium channel in pups born to 52 kDa SSA/Ro immunized rabbits. FASEB J 15:1539-45

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