Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL055445-01
Application #
2234022
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-08-01
Project End
2001-06-30
Budget Start
1996-08-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Kim, Sun-Ok; Avraham, Shalom; Jiang, Shuxian et al. (2004) Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors. Cancer 101:1018-27
Lee, Tae-Hee; Avraham, Hava Karsenty; Jiang, Shuxian et al. (2003) Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability. J Biol Chem 278:5277-84
McShan, Gina D; Zagozdzon, Radoslaw; Park, Shin-Young et al. (2002) Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration. Int J Oncol 21:197-205
Zhang, X F; Wang, J F; Matczak, E et al. (2001) Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells. Blood 97:3342-8
Miralem, T; Steinberg, R; Price, D et al. (2001) VEGF(165) requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells. Oncogene 20:5511-24
Koziak, K; Kaczmarek, E; Park, S Y et al. (2001) RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase. Br J Haematol 114:134-40
Park, S Y; Avraham, H; Avraham, S (2000) Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation. J Biol Chem 275:19768-77
Avraham, H; Avraham, S; Taniguchi, Y (2000) Receptor protein tyrosine phosphatases in hematopoietic cells. J Hematother Stem Cell Res 9:425-32
Avraham, H; Park, S Y; Schinkmann, K et al. (2000) RAFTK/Pyk2-mediated cellular signalling. Cell Signal 12:123-33
Radisavljevic, Z; Avraham, H; Avraham, S (2000) Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric oxide pathway and modulates migration of brain microvascular endothelial cells. J Biol Chem 275:20770-4

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