Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL055534-01
Application #
2234130
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1996-02-01
Project End
2001-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
City
Torrance
State
CA
Country
United States
Zip Code
90502
Walther, Frans J; Gordon, Larry M; Waring, Alan J (2016) Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants. Biomed Hub 1:
Frey, Shelli L; Pocivavsek, Luka; Waring, Alan J et al. (2010) Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B. Am J Physiol Lung Cell Mol Physiol 298:L335-47
Pocivavsek, Luka; Frey, Shelli L; Krishan, Kapilanjan et al. (2008) Lateral stress relaxation and collapse in lipid monolayers. Soft Matter 4:2019-2029
de Visser, Y P; Walther, F J; Laghmani, E H et al. (2008) Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury. Eur Respir J 31:633-44
Sarker, Muzaddid; Waring, Alan J; Walther, Frans J et al. (2007) Structure of mini-B, a functional fragment of surfactant protein B, in detergent micelles. Biochemistry 46:11047-56
Walther, Frans J; Waring, Alan J; Sherman, Mark A et al. (2007) Hydrophobic surfactant proteins and their analogues. Neonatology 91:303-10
Walther, Frans J; Waring, Alan J; Hernandez-Juviel, Jose M et al. (2007) Dynamic surface activity of a fully synthetic phospholipase-resistant lipid/peptide lung surfactant. PLoS One 2:e1039
ter Horst, Simone A J; Fijlstra, Margot; Sengupta, Sujata et al. (2006) Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury. BMC Pulm Med 6:8
Walther, Frans J; Hernandez-Juviel, Jose M; Gordon, Larry M et al. (2005) Comparison of three lipid formulations for synthetic surfactant with a surfactant protein B analog. Exp Lung Res 31:563-79
Waring, A J; Walther, F J; Gordon, L M et al. (2005) The role of charged amphipathic helices in the structure and function of surfactant protein B. J Pept Res 66:364-74

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