Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL055678-02
Application #
2748370
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1997-04-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Xu, Meifeng; Ashraf, Muhammad (2002) Melatonin protection against lethal myocyte injury induced by doxorubicin as reflected by effects on mitochondrial membrane potential. J Mol Cell Cardiol 34:75-9
Kudo, Mitsuhiro; Wang, Yigang; Xu, Meifeng et al. (2002) Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway. Am J Physiol Heart Circ Physiol 283:H296-301
Xu, M; Wang, Y; Hirai, K et al. (2001) Calcium preconditioning inhibits mitochondrial permeability transition and apoptosis. Am J Physiol Heart Circ Physiol 280:H899-908
Wang, Y; Kudo, M; Xu, M et al. (2001) Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. J Mol Cell Cardiol 33:2037-46
Wang, Y; Takashi, E; Xu, M et al. (2001) Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxide. Circulation 104:85-90
Xu, M; Wang, Y; Ayub, A et al. (2001) Mitochondrial K(ATP) channel activation reduces anoxic injury by restoring mitochondrial membrane potential. Am J Physiol Heart Circ Physiol 281:H1295-303
Takashi, E; Ashraf, M (2000) Pathologic assessment of myocardial cell necrosis and apoptosis after ischemia and reperfusion with molecular and morphological markers. J Mol Cell Cardiol 32:209-24
Wang, Y; Hirai, K; Ashraf, M (1999) Activation of mitochondrial ATP-sensitive K(+) channel for cardiac protection against ischemic injury is dependent on protein kinase C activity. Circ Res 85:731-41
Wang, Y; Ashraf, M (1999) Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardium. Circ Res 84:1156-65
Takashi, E; Wang, Y; Ashraf, M (1999) Activation of mitochondrial K(ATP) channel elicits late preconditioning against myocardial infarction via protein kinase C signaling pathway. Circ Res 85:1146-53

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