Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL055714-01A1
Application #
2234344
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1996-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Brodbeck, William G; Voskerician, Gabriela; Ziats, Nicholas P et al. (2003) In vivo leukocyte cytokine mRNA responses to biomaterials are dependent on surface chemistry. J Biomed Mater Res A 64:320-9
McNally, Amy K; Anderson, James M (2003) Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022. Am J Pathol 163:1147-56
Collier, Terry O; Anderson, James M; Kikuchi, Akihiko et al. (2002) Adhesion behavior of monocytes, macrophages, and foreign body giant cells on poly (N-isopropylacrylamide) temperature-responsive surfaces. J Biomed Mater Res 59:136-43
Brodbeck, William G; Patel, Jasmine; Voskerician, Gabriela et al. (2002) Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo. Proc Natl Acad Sci U S A 99:10287-92
McNally, Amy K; Anderson, James M (2002) Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation. Am J Pathol 160:621-30
Collier, T O; Anderson, J M (2002) Protein and surface effects on monocyte and macrophage adhesion, maturation, and survival. J Biomed Mater Res 60:487-96
Brodbeck, William G; Shive, Mathew S; Colton, Erica et al. (2002) Interleukin-4 inhibits tumor necrosis factor-alpha-induced and spontaneous apoptosis of biomaterial-adherent macrophages. J Lab Clin Med 139:90-100
Brodbeck, W G; Shive, M S; Colton, E et al. (2001) Influence of biomaterial surface chemistry on the apoptosis of adherent cells. J Biomed Mater Res 55:661-8
Jenney, C R; Anderson, J M (2000) Adsorbed serum proteins responsible for surface dependent human macrophage behavior. J Biomed Mater Res 49:435-47
Nakayama, Y; Anderson, J M; Matsuda, T (2000) Laboratory-scale mass production of a multi-micropatterned grafted surface with different polymer regions. J Biomed Mater Res 53:584-91

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