Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL056153-01
Application #
2234754
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Temple University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Ahmad, S S; London, F S; Walsh, P N (2003) The assembly of the factor X-activating complex on activated human platelets. J Thromb Haemost 1:48-59
Ahmad, Syed S; Walsh, Peter N (2002) Coordinate binding studies of the substrate (factor X) with the cofactor (factor VIII) in the assembly of the factor X activating complex on the activated platelet surface. Biochemistry 41:11269-76
Wilkinson, Frank H; Ahmad, Syed S; Walsh, Peter N (2002) The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating complex. J Biol Chem 277:5734-41
Wilkinson, Frank H; London, Fredda S; Walsh, Peter N (2002) Residues 88-109 of factor IXa are important for assembly of the factor X activating complex. J Biol Chem 277:5725-33
Sinha, Dipali; Marcinkiewicz, Mariola; Gailani, David et al. (2002) Molecular cloning and biochemical characterization of rabbit factor XI. Biochem J 367:49-56
Walsh, Peter N; Ahmad, Syed S (2002) Proteases in blood clotting. Essays Biochem 38:95-111
Gailani, D; Ho, D; Sun, M F et al. (2001) Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential. Blood 97:3117-22
Sun, M F; Baglia, F A; Ho, D et al. (2001) Defective binding of factor XI-N248 to activated human platelets. Blood 98:125-9
Baglia, F A; Walsh, P N (2000) Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa. J Biol Chem 275:20514-9
London, F S; Walsh, P N (2000) Zymogen factor IX potentiates factor IXa-catalyzed factor X activation. Biochemistry 39:9850-8

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