Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL056264-02
Application #
2234850
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1995-08-04
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
O'Toole, Timothy E; Bialkowska, Katarzyna; Li, Xiaohong et al. (2011) Tiam1 is recruited to ?1-integrin complexes by 14-3-3? where it mediates integrin-induced Rac1 activation and motility. J Cell Physiol 226:2965-78
Bialkowska, Katarzyna; Saido, Takaomi C; Fox, Joan E B (2005) SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes. J Cell Sci 118:381-95
Bialkowska, Katarzyna; Zaffran, Yona; Meyer, Sylvie C et al. (2003) 14-3-3 zeta mediates integrin-induced activation of Cdc42 and Rac. Platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3 zeta. J Biol Chem 278:33342-50
Austin, Richard C; Fox, Joan E B; Werstuck, Geoff H et al. (2002) Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion. J Biol Chem 277:47106-13
Kulkarni, Sucheta; Goll, Darrel E; Fox, Joan E B (2002) Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreading. J Biol Chem 277:24435-41
Fox, J E (2001) Cytoskeletal proteins and platelet signaling. Thromb Haemost 86:198-213
Reddy, K B; Bialkowska, K; Fox, J E (2001) Dynamic modulation of cytoskeletal proteins linking integrins to signaling complexes in spreading cells. Role of skelemin in initial integrin-induced spreading. J Biol Chem 276:28300-8
Zaffran, Y; Meyer, S C; Negrescu, E et al. (2000) Signaling across the platelet adhesion receptor glycoprotein Ib-IX induces alpha IIbbeta 3 activation both in platelets and a transfected Chinese hamster ovary cell system. J Biol Chem 275:16779-87
Kulkarni, S; Fox, J E (2000) Localization of calpain by immunofluorescence in adherent cells. Methods Mol Biol 144:151-9
Bialkowska, K; Kulkarni, S; Du, X et al. (2000) Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active. J Cell Biol 151:685-96

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