Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL056285-03
Application #
2800553
Study Section
Project Start
1997-05-01
Project End
2001-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Coya, Juan Manuel; Akinbi, Henry T; Sáenz, Alejandra et al. (2015) Natural Anti-Infective Pulmonary Proteins: In Vivo Cooperative Action of Surfactant Protein SP-A and the Lung Antimicrobial Peptide SP-BN. J Immunol 195:1628-36
Yang, Li; Johansson, Jan; Ridsdale, Ross et al. (2010) Surfactant protein B propeptide contains a saposin-like protein domain with antimicrobial activity at low pH. J Immunol 184:975-83
Perez-Gil, Jesus; Weaver, Timothy E (2010) Pulmonary surfactant pathophysiology: current models and open questions. Physiology (Bethesda) 25:132-41
Ikegami, Machiko; Weaver, Timothy E; Grant, Shawn N et al. (2009) Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation. Am J Respir Cell Mol Biol 41:433-9
Bein, Kiflai; Wesselkamper, Scott C; Liu, Xiangdong et al. (2009) Surfactant-associated protein B is critical to survival in nickel-induced injury in mice. Am J Respir Cell Mol Biol 41:226-36
Ryan, Marnie A; Akinbi, Henry T; Serrano, Alicia G et al. (2006) Antimicrobial activity of native and synthetic surfactant protein B peptides. J Immunol 176:416-25
Akei, Hiroko; Whitsett, Jeffrey A; Buroker, Michelle et al. (2006) Surface tension influences cell shape and phagocytosis in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 291:L572-9
Bridges, James P; Weaver, Timothy E (2006) Use of transgenic mice to study lung morphogenesis and function. ILAR J 47:22-31
Ikegami, Machiko; Whitsett, Jeffrey A; Martis, Prithy C et al. (2005) Reversibility of lung inflammation caused by SP-B deficiency. Am J Physiol Lung Cell Mol Physiol 289:L962-70
Melton, Kristin R; Nesslein, Lori L; Ikegami, Machiko et al. (2003) SP-B deficiency causes respiratory failure in adult mice. Am J Physiol Lung Cell Mol Physiol 285:L543-9

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