Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL056421-01
Application #
2234949
Study Section
Special Emphasis Panel (ZRG2-RAP (01))
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Type
Organized Research Units
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Johnson, Robert M; Ho, Ye-Shih; Yu, Dae-Yeul et al. (2010) The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism. Free Radic Biol Med 48:519-25
Johnson, Robert M; Goyette Jr, Gerard; Ravindranath, Y et al. (2005) Hemoglobin autoxidation and regulation of endogenous H2O2 levels in erythrocytes. Free Radic Biol Med 39:1407-17
Kasahara, Emiko; Lin, Li-Ren; Ho, Ye-Shih et al. (2005) SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci 46:3426-34
Ho, Ye-Shih; Xiong, Ye; Ma, Wanchao et al. (2004) Mice lacking catalase develop normally but show differential sensitivity to oxidant tissue injury. J Biol Chem 279:32804-12
Bajt, Mary Lynn; Ho, Ye-Shih; Vonderfecht, Steven L et al. (2002) Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice. Antioxid Redox Signal 4:733-40
Johnson, Robert M; Goyette Jr, Gerard; Ravindranath, Yaddanapudi et al. (2002) Oxidation of glutathione peroxidase-deficient red cells by organic peroxides. Blood 100:1515-6
Strayer, Marlene; Savani, Rashmin C; Gonzales, Linda W et al. (2002) Human surfactant protein B promoter in transgenic mice: temporal, spatial, and stimulus-responsive regulation. Am J Physiol Lung Cell Mol Physiol 282:L394-404
Reddy, V N; Giblin, F J; Lin, L R et al. (2001) Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice. Invest Ophthalmol Vis Sci 42:3247-55
Yoshida, T; Maulik, N; Ho, Y S et al. (2001) H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene. Circulation 103:1695-701
Chen, Z; Chua, C C; Ho, Y S et al. (2001) Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol 280:H2313-20

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