Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL056441-02S1
Application #
2470047
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1995-09-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Nagatomo, Toshihisa; January, Craig T; Ye, Bin et al. (2002) Rate-dependent QT shortening mechanism for the LQT3 deltaKPQ mutant. Cardiovasc Res 54:624-9
Nagatomo, T; January, C T; Makielski, J C (2000) Preferential block of late sodium current in the LQT3 DeltaKPQ mutant by the class I(C) antiarrhythmic flecainide. Mol Pharmacol 57:101-7
Zhang, S; Zhou, Z; Gong, Q et al. (1999) Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ Res 84:989-98
Makielski, J C; Limberis, J; Fan, Z et al. (1999) Intrinsic lidocaine affinity for Na channels expressed in Xenopus oocytes depends on alpha (hH1 vs. rSkM1) and beta 1 subunits. Cardiovasc Res 42:503-9
Nagatomo, T; Fan, Z; Ye, B et al. (1998) Temperature dependence of early and late currents in human cardiac wild-type and long Q-T DeltaKPQ Na+ channels. Am J Physiol 275:H2016-24
Fan, Z; George Jr, A L; Kyle, J W et al. (1996) Two human paramyotonia congenita mutations have opposite effects on lidocaine block of Na+ channels expressed in a mammalian cell line. J Physiol 496 ( Pt 1):275-86
Undrovinas, A I; Makielski, J C (1996) Blockade of lysophosphatidylcholine-modified cardiac Na channels by a lidocaine derivative QX-222. Am J Physiol 271:H790-7
Shander, G S; Undrovinas, A I; Makielski, J C (1996) Rapid onset of lysophosphatidylcholine-induced modification of whole cell cardiac sodium current kinetics. J Mol Cell Cardiol 28:743-53
Makielski, J C (1996) The heart sodium channel phenotype for inactivation and lidocaine block. Jpn Heart J 37:733-9
Makielski, J C; Limberis, J T; Chang, S Y et al. (1996) Coexpression of beta 1 with cardiac sodium channel alpha subunits in oocytes decreases lidocaine block. Mol Pharmacol 49:30-9