Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL056773-01
Application #
2235233
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1996-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Michigan State University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824

  Publications

Qin, Ling; Mills, Denise A; Hiser, Carrie et al. (2007) Crystallographic location and mutational analysis of Zn and Cd inhibitory sites and role of lipidic carboxylates in rescuing proton path mutants in cytochrome c oxidase. Biochemistry 46:6239-48
Harman, Christine A; Turman, Melissa V; Kozak, Kevin R et al. (2007) Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides. J Biol Chem 282:28096-105
Wada, Masayuki; DeLong, Cynthia J; Hong, Yu H et al. (2007) Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem 282:22254-66
Harman, Christine A; Rieke, Caroline Jill; Garavito, R Michael et al. (2004) Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid. J Biol Chem 279:42929-35
Garavito, R Michael; Mulichak, Anne M (2003) The structure of mammalian cyclooxygenases. Annu Rev Biophys Biomol Struct 32:183-206
Garavito, R Michael; Malkowski, Michael G; DeWitt, David L (2002) The structures of prostaglandin endoperoxide H synthases-1 and -2. Prostaglandins Other Lipid Mediat 68-69:129-52
Lin, Henry J; Lakkides, Karen M; Keku, Temitope O et al. (2002) Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. Cancer Epidemiol Biomarkers Prev 11:1305-15
Malkowski, M G; Thuresson, E D; Lakkides, K M et al. (2001) Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1. J Biol Chem 276:37547-55
Garavito, R M; Ferguson-Miller, S (2001) Detergents as tools in membrane biochemistry. J Biol Chem 276:32403-6
Thuresson, E D; Lakkides, K M; Rieke, C J et al. (2001) Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid. J Biol Chem 276:10347-57

Showing the most recent 10 out of 16 publications