Structural Biology of Prostaglandin Biosynthesis

Garavito, R Michael

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 1R01HL056773-01
• Application #: 2235233
• Study Section: Biophysical Chemistry Study Section (BBCB)
• Project Start: 1996-07-01
• Project End: 2000-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: Michigan State University
• Department: Biochemistry
• Type: Schools of Arts and Sciences
• DUNS #: 193247145
• City: East Lansing
• State: MI
• Country: United States
• Zip Code: 48824

Publications

Qin, Ling; Mills, Denise A; Hiser, Carrie et al. (2007) Crystallographic location and mutational analysis of Zn and Cd inhibitory sites and role of lipidic carboxylates in rescuing proton path mutants in cytochrome c oxidase. Biochemistry 46:6239-48

Harman, Christine A; Turman, Melissa V; Kozak, Kevin R et al. (2007) Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides. J Biol Chem 282:28096-105

Wada, Masayuki; DeLong, Cynthia J; Hong, Yu H et al. (2007) Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem 282:22254-66

Harman, Christine A; Rieke, Caroline Jill; Garavito, R Michael et al. (2004) Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid. J Biol Chem 279:42929-35

Garavito, R Michael; Mulichak, Anne M (2003) The structure of mammalian cyclooxygenases. Annu Rev Biophys Biomol Struct 32:183-206

Garavito, R Michael; Malkowski, Michael G; DeWitt, David L (2002) The structures of prostaglandin endoperoxide H synthases-1 and -2. Prostaglandins Other Lipid Mediat 68-69:129-52

Lin, Henry J; Lakkides, Karen M; Keku, Temitope O et al. (2002) Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. Cancer Epidemiol Biomarkers Prev 11:1305-15

Garavito, R M; Ferguson-Miller, S (2001) Detergents as tools in membrane biochemistry. J Biol Chem 276:32403-6

Thuresson, E D; Lakkides, K M; Rieke, C J et al. (2001) Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid. J Biol Chem 276:10347-57

Thuresson, E D; Malkowski, M G; Lakkides, K M et al. (2001) Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases. J Biol Chem 276:10358-65