Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL056850-01
Application #
2235286
Study Section
Pathology A Study Section (PTHA)
Project Start
1996-08-01
Project End
2001-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Cascella, Teresa; Radhakrishnan, Yashwanth; Maile, Laura A et al. (2010) Aldosterone enhances IGF-I-mediated signaling and biological function in vascular smooth muscle cells. Endocrinology 151:5851-64
Shen, Xinchun; Xi, Gang; Radhakrishnan, Yashwanth et al. (2010) Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells. Cell Mol Life Sci 67:3893-903
Shen, Xinchun; Xi, Gang; Radhakrishnan, Yashwanth et al. (2010) PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival. J Biol Chem 285:29416-24
Xi, Gang; Shen, Xinchun; Radhakrishnan, Yashwanth et al. (2010) Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells. Endocrinology 151:3611-23
Maile, Laura A; Busby, Walker H; Nichols, Timothy C et al. (2010) A monoclonal antibody against alphaVbeta3 integrin inhibits development of atherosclerotic lesions in diabetic pigs. Sci Transl Med 2:18ra11
Xi, Gang; Shen, Xinchun; Clemmons, David R (2010) p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation. J Biol Chem 285:6937-51
Maile, Laura A; Allen, Lee B; Veluvolu, Umadevi et al. (2009) Identification of compounds that inhibit IGF-I signaling in hyperglycemia. Exp Diabetes Res 2009:267107
Shen, Xinchun; Xi, Gang; Radhakrishnan, Yashwanth et al. (2009) Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells. Mol Cell Proteomics 8:1539-51
Radhakrishnan, Yashwanth; Maile, Laura A; Ling, Yan et al. (2008) Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells. J Biol Chem 283:16320-31
Maile, Laura A; Capps, Byron E; Miller, Emily C et al. (2008) Integrin-associated protein association with SRC homology 2 domain containing tyrosine phosphatase substrate 1 regulates igf-I signaling in vivo. Diabetes 57:2637-43

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