Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL057125-01
Application #
2030386
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1996-12-15
Project End
1999-11-30
Budget Start
1996-12-15
Budget End
1997-11-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Carmona, Eva M; Kottom, Theodore J; Hebrink, Deanne M et al. (2012) Glycosphingolipids mediate pneumocystis cell wall ?-glucan activation of the IL-23/IL-17 axis in human dendritic cells. Am J Respir Cell Mol Biol 47:50-9
Kottom, Theodore J; Burgess, Joshua W; Limper, Andrew H (2011) Pneumocystis carinii interactions with lung epithelial cells and matrix proteins induce expression and activity of the PcSte20 kinase with subsequent phosphorylation of the downstream cell wall biosynthesis kinase PcCbk1. Infect Immun 79:4157-64
Lebron, Frances; Vassallo, Robert; Puri, Vishwajeet et al. (2003) Pneumocystis carinii cell wall beta-glucans initiate macrophage inflammatory responses through NF-kappaB activation. J Biol Chem 278:25001-8
Yong, Suk-Joong; Vuk-Pavlovic, Zvezdana; Standing, Joseph E et al. (2003) Surfactant protein D-mediated aggregation of Pneumocystis carinii impairs phagocytosis by alveolar macrophages. Infect Immun 71:1662-71
Kottom, Theodore J; Limper, Andrew H (2003) Microarray analysis of lung epithelial responses to Pneumocystis carinii. J Eukaryot Microbiol 50 Suppl:629
Limper, Andrew H; Lebron, Frances; Evans, Scott E et al. (2003) Pneumocystis carinii: cell wall beta-glucan-mediated pulmonary inflammation. J Eukaryot Microbiol 50 Suppl:646
Kottom, Theodore J; Kohler, Julia R; Thomas Jr, Charles F et al. (2003) Lung epithelial cells and extracellular matrix components induce expression of Pneumocystis carinii STE20, a gene complementing the mating and pseudohyphal growth defects of STE20 mutant yeast. Infect Immun 71:6463-71
Hahn, Peter Y; Evans, Scott E; Kottom, Theodore J et al. (2003) Pneumocystis carinii cell wall beta-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated mechanism. J Biol Chem 278:2043-50
Kottom, Theodore J; Limper, Andrew H (2002) Subtractive hybridization analysis of Pneumocystis carinii gene activation induced by interaction with lung epithelial cells and matrix. Chest 121:78S-79S
Kottom, T J; Limper, A H (2001) A gene complex mediating cyst wall assembly and integrity in Pneumocystis carinii. J Eukaryot Microbiol Suppl:133S

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