Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL057314-02
Application #
2638082
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1997-01-01
Project End
1999-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Harvard University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Gladysheva, Inna P; Sazonova, Irina Y; Chowdhry, Shakeel A et al. (2002) Chimerism reveals a role for the streptokinase Beta -domain in nonproteolytic active site formation, substrate, and inhibitor interactions. J Biol Chem 277:26846-51
Sazonova, I Y; Houng, A K; Chowdhry, S A et al. (2001) The mechanism of a bacterial plasminogen activator intermediate between streptokinase and staphylokinase. J Biol Chem 276:12609-13
Liu, L; Sazonova, I Y; Turner, R B et al. (2000) Leucine 42 in the fibronectin motif of streptokinase plays a critical role in fibrin-independent plasminogen activation. J Biol Chem 275:37686-91
Robinson, B R; Houng, A K; Reed, G L (2000) Catalytic life of activated factor XIII in thrombi. Implications for fibrinolytic resistance and thrombus aging. Circulation 102:1151-7
Fitzgerald, M L; Moore, K J; Freeman, M W et al. (2000) Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages. J Immunol 164:2692-700
Polgar, J; Reed, G L (1999) A critical role for N-ethylmaleimide-sensitive fusion protein (NSF) in platelet granule secretion. Blood 94:1313-8
Reed, G L; Houng, A K (1999) The contribution of activated factor XIII to fibrinolytic resistance in experimental pulmonary embolism. Circulation 99:299-304
Fitzgerald, M L; Reed, G L (1999) Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution. Biochem J 342 ( Pt 2):353-60
Reed, G L; Houng, A K; Liu, L et al. (1999) A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator. Proc Natl Acad Sci U S A 96:8879-83
Shi, C; Patel, A; Zhang, D et al. (1999) Plasminogen is not required for neointima formation in a mouse model of vein graft stenosis. Circ Res 84:883-90

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