Abstract

The lungs are the most highly perfused organs in the body. Disease processes that interfere with perfusion, such as pulmonary thromboembolism can be difficult to diagnose, and are potentially lethal. The investigators have developed novel methods for perfusion MRI of the lungs.
The specific aims of this research are: 1. To develop the methodology for imaging and quantification of pulmonary perfusion using dynamic first-pass imaging after administration of a bolus of gadolinium chelate. 2. To quantify perfusion by this technique and correlate the results with absolute flow as determined by microspheres in an animal model, using pharmacologic agents to modulate perfusion. 3. To optimize MR angiography for patients unable to suspend respiration for lengthy periods. 4. The determine the sensitivity and specificity of perfusion MRI and MR angiography for the diagnosis of pulmonary embolism in an animal model. To determine the time course of enhancement of perfusion defects caused by pulmonary emboli. 5. To perform a preliminary study of the MRI perfusion and MR angiography methods in patients with suspected pulmonary embolism who have high probability ventilation-perfusion scans. To use the HASTE technique to detect lung abnormalities such as infiltrates, masses or bulla that could mimic perfusion defects from a pulmonary embolus.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL057437-01A1
Application #
2403753
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1997-07-01
Project End
2000-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Napadow, V J; Mai, V; Bankier, A et al. (2001) Determination of regional pulmonary parenchymal strain during normal respiration using spin inversion tagged magnetization MRI. J Magn Reson Imaging 13:467-74
Mai, V M; Chen, Q; Bankier, A A et al. (2001) Effect of lung inflation on arterial spin labeling signal in MR perfusion imaging of human lung. J Magn Reson Imaging 13:954-9
Mai, V M; Bankier, A A; Prasad, P V et al. (2001) MR ventilation-perfusion imaging of human lung using oxygen-enhanced and arterial spin labeling techniques. J Magn Reson Imaging 14:574-9
Chen, Q; Mai, V M; Bankier, A A et al. (2001) Ultrafast MR grid-tagging sequence for assessment of local mechanical properties of the lungs. Magn Reson Med 45:24-8
Mai, V M; Chen, Q; Bankier, A A et al. (2000) Multiple inversion recovery MR subtraction imaging of human ventilation from inhalation of room air and pure oxygen. Magn Reson Med 43:913-6
Mai, V M; Chen, Q; Bankier, A A et al. (2000) Imaging pulmonary blood flow and perfusion using phase-sensitive selective inversion recovery. Magn Reson Med 43:793-5
Mai, V M; Knight-Scott, J; Edelman, R R et al. (2000) 1H magnetic resonance imaging of human lung using inversion recovery turbo spin echo. J Magn Reson Imaging 11:616-21
Mai, V M; Chen, Q; Li, W et al. (2000) Effect of respiratory phases on MR lung signal intensity and lung conspicuity using segmented multiple inversion recovery turbo spin echo (MIR-TSE). Magn Reson Med 43:760-3
Chen, Q; Levin, D L; Kim, D et al. (1999) Pulmonary disorders: ventilation-perfusion MR imaging with animal models. Radiology 213:871-9
Hatabu, H; Tadamura, E; Levin, D L et al. (1999) Quantitative assessment of pulmonary perfusion with dynamic contrast-enhanced MRI. Magn Reson Med 42:1033-8

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