Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL057527-12A2
Application #
2631026
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1984-02-01
Project End
2002-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Wayne State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Evans, Hedeel Guy; Fernando, Roshini; Vaishnav, Asmita et al. (2014) Intersubunit communication in the dihydroorotase-aspartate transcarbamoylase complex of Aquifex aeolicus. Protein Sci 23:100-9
Edwards, Brian F P; Fernando, Roshini; Martin, Philip D et al. (2013) The mononuclear metal center of type-I dihydroorotase from Aquifex aeolicus. BMC Biochem 14:36
Zhang, Pengfei; Martin, Philip D; Purcarea, Cristina et al. (2009) Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis. Biochemistry 48:766-78
Martin, Philip D; Purcarea, Cristina; Zhang, Pengfei et al. (2005) The crystal structure of a novel, latent dihydroorotase from Aquifex aeolicus at 1.7A resolution. J Mol Biol 348:535-47
Malkowski, M G; Martin, P D; Lord, S T et al. (1997) Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16. Biochem J 326 ( Pt 3):815-22
Malkowski, M G; Martin, P D; Guzik, J C et al. (1997) The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding. Protein Sci 6:1438-48
Martin, P D; Malkowski, M G; Box, J et al. (1997) New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK. Structure 5:1681-93
Cook, W J; Martin, P D; Edwards, B F et al. (1997) Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution. Biochemistry 36:1621-7