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Evans, Hedeel Guy; Fernando, Roshini; Vaishnav, Asmita et al. (2014) Intersubunit communication in the dihydroorotase-aspartate transcarbamoylase complex of Aquifex aeolicus. Protein Sci 23:100-9
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Edwards, Brian F P; Fernando, Roshini; Martin, Philip D et al. (2013) The mononuclear metal center of type-I dihydroorotase from Aquifex aeolicus. BMC Biochem 14:36
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Zhang, Pengfei; Martin, Philip D; Purcarea, Cristina et al. (2009) Dihydroorotase from the hyperthermophile Aquifex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis. Biochemistry 48:766-78
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Martin, Philip D; Purcarea, Cristina; Zhang, Pengfei et al. (2005) The crystal structure of a novel, latent dihydroorotase from Aquifex aeolicus at 1.7A resolution. J Mol Biol 348:535-47
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Malkowski, M G; Martin, P D; Lord, S T et al. (1997) Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16. Biochem J 326 ( Pt 3):815-22
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Malkowski, M G; Martin, P D; Guzik, J C et al. (1997) The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding. Protein Sci 6:1438-48
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Martin, P D; Malkowski, M G; Box, J et al. (1997) New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK. Structure 5:1681-93
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Cook, W J; Martin, P D; Edwards, B F et al. (1997) Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution. Biochemistry 36:1621-7
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