Ribozyme Mediated Repair of Sickle B-Globin Transcripts

Sullenger, Bruce Alan

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 1R01HL057606-01
• Application #: 2030843
• Study Section: Special Emphasis Panel (ZHL1-CSR-B (S1))
• Project Start: 1996-09-30
• Project End: 2000-08-31
• Budget Start: 1996-09-30
• Budget End: 1997-08-31
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: Duke University
• Department: Surgery
• Type: Schools of Medicine
• DUNS #: 071723621
• City: Durham
• State: NC
• Country: United States
• Zip Code: 27705

Publications

Lan, N; Rooney, B L; Lee, S W et al. (2000) Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA. Mol Ther 2:245-55

Howrey, R P; El-Alfondi, M; Phillips, K L et al. (2000) An in vitro system for efficiently evaluating gene therapy approaches to hemoglobinopathies. Gene Ther 7:215-23

Lan, N; Howrey, R P; Lee, S W et al. (1998) Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors. Science 280:1593-6