Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL057872-01
Application #
2235469
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1996-08-01
Project End
2001-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Physiology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Nishimura, Mayuko; Kumsta, Caroline; Kaushik, Gaurav et al. (2014) A dual role for integrin-linked kinase and ?1-integrin in modulating cardiac aging. Aging Cell 13:431-40
Manso, Ana Maria; Kang, Seok-Min; Plotnikov, Sergey V et al. (2009) Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration. Am J Physiol Heart Circ Physiol 296:H627-38
Lei, Li; Liu, Dinggang; Huang, Yan et al. (2008) Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling. Mol Cell Biol 28:794-802
Elsherif, Laila; Huang, Michael S; Shai, Shaw-Yung et al. (2008) Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. Circ Res 102:1109-17
Menon, Bindu; Johnson, Jennifer N; Ross, Robert S et al. (2007) Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins. J Mol Cell Cardiol 42:653-61
Zemljic-Harpf, Alice E; Miller, Joel C; Henderson, Scott A et al. (2007) Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Mol Cell Biol 27:7522-37
Oh, Yong-Seog; Jong, Ambrose Y; Kim, Dave T et al. (2006) Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm 3:728-36
Manso, Ana Maria; Elsherif, Laila; Kang, Seok-Min et al. (2006) Integrins, membrane-type matrix metalloproteinases and ADAMs: potential implications for cardiac remodeling. Cardiovasc Res 69:574-84
Menon, Bindu; Krishnamurthy, Prasanna; Kaverina, Ekaterina et al. (2006) Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway. Basic Res Cardiol 101:485-93
Menon, Bindu; Singh, Mahipal; Ross, Robert S et al. (2006) beta-Adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of beta1 integrin signaling and mitochondrial pathway. Am J Physiol Cell Physiol 290:C254-61

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