Glutathione and Cell Signaling in Atherosclerosis

Darley-Usmar, Victor M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL058031-02
• Application #: 6184378
• Study Section: Experimental Cardiovascular Sciences Study Section (ECS)
• Project Start: 1999-08-15
• Project End: 2002-07-31
• Budget Start: 2000-08-01
• Budget End: 2001-07-31
• Support Year: 2
• Fiscal Year: 2000
• Total Cost: $229,092

Institution

• Name: University of Alabama Birmingham
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 004514360
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35294

Publications

Byon, Chang Hyun; Javed, Amjad; Dai, Qun et al. (2008) Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem 283:15319-27

Benavides, Gloria A; Squadrito, Giuseppe L; Mills, Robert W et al. (2007) Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A 104:17977-82

Shiva, Sruti; Huang, Zhi; Grubina, Rozalina et al. (2007) Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circ Res 100:654-61

Landar, Aimee; Shiva, Sruti; Levonen, Anna-Liisa et al. (2006) Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. Biochem J 394:185-95

Landar, Aimee; Oh, Joo-Yeun; Giles, Niroshini M et al. (2006) A sensitive method for the quantitative measurement of protein thiol modification in response to oxidative stress. Free Radic Biol Med 40:459-68

Watanabe, Nobuo; Zmijewski, Jaroslaw W; Takabe, Wakako et al. (2006) Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol 168:1737-48

Gutierrez, Jessica; Ballinger, Scott W; Darley-Usmar, Victor M et al. (2006) Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ Res 99:924-32

Zmijewski, J W; Landar, A; Watanabe, N et al. (2005) Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium. Biochem Soc Trans 33:1385-9

Zmijewski, Jaroslaw W; Moellering, Douglas R; Le Goffe, Claire et al. (2005) Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells. Am J Physiol Heart Circ Physiol 289:H852-61

Darley-Usmar, Victor (2004) The powerhouse takes control of the cell; the role of mitochondria in signal transduction. Free Radic Biol Med 37:753-4