Abstract

This project is designed to determine the nature, extent and molecular mechanisms responsible for impaired fibrinolysis in White, Black, hispanic and American indian populations with respect to the presence or absence of diabetes. The overall objective is to determine whether impairments of fibrinolysis underlie subclinical and clinical vascular disease in diabetes in specific populations with and without accelerated microvascular disease. The results of this project should clarify the extent to which results obtained in experimental animals pertain directly to diabetes in human subjects. This study of 2,400 plasma samples from two major epidemiological studies (the insulin Resistance in Atherosclerosis Study and the Strong heart Study) will also assist in the interpretation of results from clinical studies) and from platelet activation experiments.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL058329-02
Application #
2460240
Study Section
Special Emphasis Panel (ZHL1-CSR-Y)
Project Start
1996-09-15
Project End
2001-07-31
Budget Start
1997-08-01
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Vermont & St Agric College
Department
Pathology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405

  Publications

Festa, A; Haffner, S M; Wagenknecht, L E et al. (2013) Longitudinal decline of ?-cell function: comparison of a direct method vs a fasting surrogate measure: the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab 98:4152-9
Lee, C C; Lorenzo, C; Haffner, S M et al. (2013) The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS). Diabetologia 56:112-20
Olson, Nels C; Sallam, Reem; Doyle, Margaret F et al. (2013) T helper cell polarization in healthy people: implications for cardiovascular disease. J Cardiovasc Transl Res 6:772-86
Olson, Nels C; Callas, Peter W; Hanley, Anthony J G et al. (2012) Circulating levels of TNF-? are associated with impaired glucose tolerance, increased insulin resistance, and ethnicity: the Insulin Resistance Atherosclerosis Study. J Clin Endocrinol Metab 97:1032-40
Williams, Ken; Tchernof, Andre; Hunt, Kelly J et al. (2008) Diabetes, abdominal adiposity, and atherogenic dyslipoproteinemia in women compared with men. Diabetes 57:3289-96
Festa, Andreas; Williams, Ken; Hanley, Anthony J G et al. (2008) Beta-cell dysfunction in subjects with impaired glucose tolerance and early type 2 diabetes: comparison of surrogate markers with first-phase insulin secretion from an intravenous glucose tolerance test. Diabetes 57:1638-44
Jaar, Bernard G; Plantinga, Laura C; Astor, Brad C et al. (2007) Novel and traditional cardiovascular risk factors for peripheral arterial disease in incident-dialysis patients. Adv Chronic Kidney Dis 14:304-13
Liu, Yongmei; Berthier-Schaad, Yvette; Plantinga, Laura et al. (2006) Functional variants in the lymphotoxin-alpha gene predict cardiovascular disease in dialysis patients. J Am Soc Nephrol 17:3158-66
Festa, Andreas; Williams, Ken; D'Agostino Jr, Ralph et al. (2006) The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study. Diabetes 55:1114-20
Festa, Andreas; Williams, Ken; Tracy, Russell P et al. (2006) Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetes. Circulation 113:1753-9

Showing the most recent 10 out of 32 publications