The long-term objectives of our research program are to create a model of how mental stress causes myocardial ischemia in patients with coronary disease (CAD), and to use this model to test treatments that improve prognosis for the approximately 50% of CAD patients who are at risk for poor outcomes because of mental stress provoked ischema.
The Specific Aims of this application concern autonomic, inflammatory, and vascular pathways that are intermediary between the central nervous system and cardiovascular system and that we believe play a key role in mental stress ischemia.
We aim to tie our prior observations regarding brain activity and myocardial blood flow during mental stress by, 1) assessing key intermediary autonomic pathways during mental stress in patients with CAD, and 2) determining the contributions of dispositional (hostility) and reactive factors (state anger) to the provocation of ischemia during mental stress. We will test hypotheses regarding, a) changes in autonomic tone, accompanying increases in levels of proteins that affect the functioning of blood vessels, and patterns of brain activity caused by mental stress and resulting in mental stress ischemia; and, b) the relationship of hostility and anger in the prediction of mental stress ischemia and the prediction of changes in autonomic tone, increases in levels of proteins that affect the functioning of blood vessels, and patterns of brain activity caused by mental stress.

Public Health Relevance

Mental Stress Ischemia contributes to poorer prognosis in patients with coronary disease. The complete modeling of this ischemia, which is the focus of this application, will help efforts to define and test treatments aimed at reducing the risk of mental stress ischemia and improve medical outcomes for patients with coronary disease. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL059619-06S1
Application #
7528970
Study Section
Special Emphasis Panel (ZRG1-BBBP-T (02))
Program Officer
Jobe, Jared B
Project Start
1998-09-01
Project End
2012-06-30
Budget Start
2008-08-15
Budget End
2009-06-30
Support Year
6
Fiscal Year
2008
Total Cost
$178,885
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Burg, Matthew M; Soufer, Robert (2014) Psychological Stress and Induced Ischemic Syndromes. Curr Cardiovasc Risk Rep 8:377
Burg, Matthew M; Meadows, Judith; Shimbo, Daichi et al. (2014) Confluence of depression and acute psychological stress among patients with stable coronary heart disease: effects on myocardial perfusion. J Am Heart Assoc 3:e000898
Youngblood, Mark W; Han, Xiao; Farooque, Pue et al. (2013) Intracranial EEG surface renderings: new insights into normal and abnormal brain function. Neuroscientist 19:238-47
Blumenfeld, Hal (2012) Impaired consciousness in epilepsy. Lancet Neurol 11:814-26
Abisse, Saddam S; Lampert, Rachel; Burg, Matthew et al. (2011) Cardiac repolarization instability during psychological stress in patients with ventricular arrhythmias. J Electrocardiol 44:678-83
Burg, Matthew M; Martens, Elisabeth J; Collins, Dorothea et al. (2011) Depression predicts elevated endothelin-1 in patients with coronary artery disease. Psychosom Med 73:2-6
Fernandez, Antonio B; Soufer, Robert; Collins, Dorothea et al. (2010) Tendency to angry rumination predicts stress-provoked endothelin-1 increase in patients with coronary artery disease. Psychosom Med 72:348-53
Lampert, Rachel; Shusterman, Vladimir; Burg, Matthew et al. (2009) Anger-induced T-wave alternans predicts future ventricular arrhythmias in patients with implantable cardioverter-defibrillators. J Am Coll Cardiol 53:774-8
Burg, Matthew M; Graeber, Brendon; Vashist, Aseem et al. (2009) Noninvasive detection of risk for emotion-provoked myocardial ischemia. Psychosom Med 71:14-20
Soufer, Robert; Jain, Hitender; Yoon, Andrew J (2009) Heart-brain interactions in mental stress-induced myocardial ischemia. Curr Cardiol Rep 11:133-40

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