Abstract

Vulnerable plaques are prone to rupture and can cause acute coronary syndromes. The goal of these 3 collaborative projects are to identify the mechanisms related to the formation and stabilization of vulnerable plaques and to develop non-invasive methods for their detection and characterization. This project will characterize vulnerable plaques by MRI in humans.
In aim 1, asymptomatic patients with dyslipidemia and patients with stroke will be screened for plaques in the thoracic aorta and carotid arteries. Plasma lipid levels will be modified by therapy with a statin or statin plus niacin (to raise HDL) and changes in plaque size and composition will be followed serially by MRI.
In aim 2, a porcine model of human coronary artery disease will be used to develop MRI techniques to detect and characterize coronary plaques, then these techniques will be applied to humans. Overall, the projects represent highly interactive efforts of experienced investigators who will develop new approaches to the vulnerable plaque using molecular biology, animal models, clinical investigation, and MRI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL061801-03
Application #
6185042
Study Section
Special Emphasis Panel (ZHL1-CSR-B (S1))
Project Start
1998-09-30
Project End
2002-08-31
Budget Start
2000-09-30
Budget End
2001-08-31
Support Year
3
Fiscal Year
2000
Total Cost
$325,100
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
114400633
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Corti, Roberto; Osende, Julio; Hutter, Randolph et al. (2007) Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: in vivo demonstration by high-resolution MRI. Atherosclerosis 190:106-13
Corti, Roberto; Fuster, Valentin; Fayad, Zahi A et al. (2005) Effects of aggressive versus conventional lipid-lowering therapy by simvastatin on human atherosclerotic lesions: a prospective, randomized, double-blind trial with high-resolution magnetic resonance imaging. J Am Coll Cardiol 46:106-12
Wentzel, Jolanda J; Corti, Roberto; Fayad, Zahi A et al. (2005) Does shear stress modulate both plaque progression and regression in the thoracic aorta? Human study using serial magnetic resonance imaging. J Am Coll Cardiol 45:846-54
Fuster, Valentin; Kim, Raymond J (2005) Frontiers in cardiovascular magnetic resonance. Circulation 112:135-44
Viles-Gonzalez, Juan F; Poon, Michael; Sanz, Javier et al. (2004) In vivo 16-slice, multidetector-row computed tomography for the assessment of experimental atherosclerosis: comparison with magnetic resonance imaging and histopathology. Circulation 110:1467-72
Moreno, Pedro R; Fuster, Valentin (2004) New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol 44:2293-300
Corti, Roberto; Osende, Julio I; Fallon, John T et al. (2004) The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging. J Am Coll Cardiol 43:464-73
Wentzel, Jolanda J; Aguiar, Silvia H; Fayad, Zahi A (2003) Vascular MRI in the diagnosis and therapy of the high risk atherosclerotic plaque. J Interv Cardiol 16:129-42
Corti, Roberto; Fuster, Valentin (2003) New understanding, diagnosis, and prognosis of atherothrombosis and the role of imaging. Am J Cardiol 91:17A-26A
Fayad, Zahi A (2002) Noncoronary and coronary atherothrombotic plaque imaging and monitoring of therapy by MRI. Neuroimaging Clin N Am 12:461-71

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