This collaborative proposal has Imaging, Biomechanics and Vascular Biology components. This combined submission seeks to identify imaging, hemodynamic, elastomechanical and pathobiologic parameters that distinguish the vulnerable atherosclerotic plaque. The Imaging component will develop and validate MR angiographic methods that yield high resolution 3D measurements of the carotid bifurcation in patients about to undergo endarterectomy. Plaque lumenal contour and composition will be validated by ex vivo MR imaging and histologic studies. Currently, identification of the specific features that make any given plaque vulnerable to rupture is hampered by the absence of a reliable, non-invasive method that can serially monitor plaque morphology in asymptomatic subjects. The coupling of high-resolution imaging with the pathophysiologic findings provided by the Biomechanics and Vascular Biology groups will allow identification of the plaque characteristics which define the vulnerable plaque. Armed with this data we could embark on a prospective monitoring program to define patients at risk.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL061806-01
Application #
2750665
Study Section
Special Emphasis Panel (ZHL1-CSR-B (S1))
Project Start
1998-09-30
Project End
2002-09-29
Budget Start
1998-09-30
Budget End
1999-09-29
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Northern California Institute Research & Education
Department
Type
DUNS #
City
San Francisco
State
CA
Country
United States
Zip Code
94121
Stroud, J S; Berger, S A; Saloner, D (2002) Numerical analysis of flow through a severely stenotic carotid artery bifurcation. J Biomech Eng 124:9-20
Coombs, B D; Rapp, J H; Ursell, P C et al. (2001) Structure of plaque at carotid bifurcation: high-resolution MRI with histological correlation. Stroke 32:2516-21
Stroud, J S; Berger, S A; Saloner, D (2000) Influence of stenosis morphology on flow through severely stenotic vessels: implications for plaque rupture. J Biomech 33:443-55
Saloner, D (1999) Flow and motion. Magn Reson Imaging Clin N Am 7:699-715