Increasing evidence links sleep disordered breathing (SDB) in children to behavioral disturbances, and to poorer performance in school and on neurocognitive tests. However, the natural history and long-term impact of SDB remains to be determined. The primary objectives of this competitive renewal are to determine the impact of SDB identified in preadolescents on subsequent school and neurocognitive performance, to assess factors, which influence the natural history of SDB in children and to ascertain whether these elements differ between Caucasians and Hispanics. An additional objective is to assess whether previously identified changes in ventilatory drive persist on subsequent evaluation. This project thus proposes a reevaluation of the Tucson Children's Assessment of Sleep Apnea (TuCASA) cohort. This cohort of children initially recruited from ages 6 through 11 years to analyze the prevalence and correlates of childhood SDB, is well characterized, and is an ideal vehicle to achieve the following specific aims: 1) to determine whether SDB in preadolescent children adversely impacts school and neurocognitive performance, growth and blood pressure in these same children approximately 4 years later, and to compare findings between Caucasians and Hispanics; 2) to calculate the 4- year incidence and remission rates and current prevalence of SDB in children who were initially studied from ages 6 through 11 years, and to assess whether there are ethnic and/or anthropometric characteristics in preadolescence that influence these rates; 3) to assess whether abnormalities previously observed in ventilatory drive persist several years later; 4) to determine whether subtle changes in executive and frontal-lobe function can be detected in children who had SDB 4 years previously using a novel test of working memory and sustained attention which incorporates electroencephalographic (EEG) measures obtained during task performance. Approximately 425 children in the TuCASA cohort will undergo a repeat unattended home polysomnogram, neurocognitive test battery, complete questionnaires related to sleep and have selected anthropometric measurements taken approximately 4 years after their initial recruitment. In addition, a subset of 50 children who had ventilatory drive studies during their initial TuCASA evaluation will have these studies repeated. A second sub study will employ a 50 pair case control subset of the TuCASA cohort who were found to have, or not have SDB 4 years previously, but who are matched on age, gender, ethnicity and intelligence. These children will undergo the Sustained Working Memory Task that assesses working memory and sustained attention with concurrent recording of EEG. These data will provide important evidence concerning the long-term impact of SDB on growth and development in children.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL062373-07
Application #
7152531
Study Section
Epidemiology of Clinical Disorders and Aging Study Section (ECDA)
Program Officer
Twery, Michael
Project Start
1999-08-15
Project End
2009-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
7
Fiscal Year
2007
Total Cost
$399,982
Indirect Cost
Name
University of Arizona
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Quan, Stuart F; Combs, Daniel; Parthasarathy, Sairam (2018) Impact of Sleep Duration and Weekend Oversleep on Body Weight and Blood Pressure in Adolescents. Southwest J Pulm Crit Care 16:31-41
Perfect, Michelle M; Beebe, Dean; Levine-Donnerstein, Deborah et al. (2016) The Development of a Clinically Relevant Sleep Modification Protocol for Youth with Type 1 Diabetes. Clin Pract Pediatr Psychol 4:227-240
Silva, Graciela E; Goodwin, James L; Vana, Kimberly D et al. (2016) Obstructive Sleep Apnea and Quality of Life: Comparison of the SAQLI, FOSQ, and SF-36 Questionnaires. Southwest J Pulm Crit Care 13:137-149
Combs, Daniel; Goodwin, James L; Quan, Stuart F et al. (2016) Longitudinal differences in sleep duration in Hispanic and Caucasian children. Sleep Med 18:61-6
Combs, Daniel; Goodwin, James L; Quan, Stuart F et al. (2016) Insomnia, Health-Related Quality of Life and Health Outcomes in Children: A Seven Year Longitudinal Cohort. Sci Rep 6:27921
Kudchadkar, Sapna R; Yaster, Myron; Punjabi, Arjun N et al. (2015) Temporal Characteristics of the Sleep EEG Power Spectrum in Critically Ill Children. J Clin Sleep Med 11:1449-54
Combs, Daniel; Goodwin, James L; Quan, Stuart F et al. (2015) Modified STOP-Bang Tool for Stratifying Obstructive Sleep Apnea Risk in Adolescent Children. PLoS One 10:e0142242
Hedger-Archbold, Kristen; Sorensen, Seth T; Goodwin, James L et al. (2014) Average heart rates of hispanic and caucasian adolescents during sleep: longitudinal analysis from the TuCASA cohort. J Clin Sleep Med 10:991-5
Silva, Graciela E; Goodwin, James L; Vana, Kimberly D et al. (2014) Restless legs syndrome, sleep, and quality of life among adolescents and young adults. J Clin Sleep Med 10:779-86
Perfect, Michelle M; Archbold, Kristen; Goodwin, James L et al. (2013) Risk of behavioral and adaptive functioning difficulties in youth with previous and current sleep disordered breathing. Sleep 36:517-525B

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