Background: Much recent effort has been directed toward controlling health care costs, but there has been little emphasis or research on prevention as a means of cost containment. This is due largely to lack of data relating to economic impact of prevention. Initial research: New data on two large Chicago cohorts followed for 22 years show that men and women with favorable baseline levels of all major CVD risk factors in middle age are at much lower age-specific risk of death from CVD, non-CVD, and all causes, and have much lower average annual Medicare costs (1984-1994), total and for CVD care, after becoming eligible at age 65 for Medicare.
Aims : General - Assess in four large Chicago population cohorts whether young adult and middle-aged risk factor status has an impact not only on average annual Medicare costs, but also on cumulative and lifetime Medicare costs, to ages 70, 75, 80, >80, including to death, and during last one to two years of life.
Specific Aims : 1) Assess relationships of CVD risk factors measured in young and middle-aged adult men and women to Medicare utilization and charges, from Medicare enrollment to death or attainment of age 70, 75, 80, >80, including in last one to two years of life. 2) Determine long-term relationship between earlier low-risk status vs. not-low-risk to subsequent Medicare health care charges. Baseline low risk is all six CVD risk factors favorable: systolic/diastolic pressure 120 mmHg/80 mmHg and no antihypertensive treatment, serum cholesterol <200 mg/dl, not currently smoking, no ECG abnormalities, no history of diabetes or heart attack. 3) Determine relationships between baseline habitual eating patterns and subsequent Medicare utilization and charges. 4) Further develop statistical methods for optimal analyses of health care expenditures. To accomplish these aims, the investigators propose to substantially extend their existing database by obtaining additional years of morbidity-mortality experience and of Medicare charge data to the year 2002. Significance: The investigators state that this research is unique and pioneering, with strong implications as to potential for both increasing longevity with health and saving money by shifting population risk factor status downward, to increase the percentage of low risk individuals from current low levels (<10 percent).

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL062684-04
Application #
6607596
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Fabsitz, Richard
Project Start
2000-09-20
Project End
2006-07-31
Budget Start
2003-08-01
Budget End
2006-07-31
Support Year
4
Fiscal Year
2003
Total Cost
$327,550
Indirect Cost
Name
Northwestern University at Chicago
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Vu, Thanh-Huyen T; Lloyd-Jones, Donald M; Liu, Kiang et al. (2016) Optimal Levels of All Major Cardiovascular Risk Factors in Younger Age and Functional Disability in Older Age: The Chicago Heart Association Detection Project in Industry 32-Year Follow-Up Health Survey. Circ Cardiovasc Qual Outcomes 9:355-63
Kizilbash, Mohammad Ali; Daviglus, Martha L; Dyer, Alan R et al. (2008) Relation of heart rate with cardiovascular disease in normal-weight individuals: the Chicago Heart Association Detection Project in Industry. Prev Cardiol 11:141-7
Carnethon, Mercedes R; Yan, Lijing; Greenland, Philip et al. (2008) Resting heart rate in middle age and diabetes development in older age. Diabetes Care 31:335-9
Yan, Lijing L; Daviglus, Martha L; Liu, Kiang et al. (2006) Midlife body mass index and hospitalization and mortality in older age. JAMA 295:190-8
Daviglus, Martha L; Lloyd-Jones, Donald M; Pirzada, Amber (2006) Preventing cardiovascular disease in the 21st century: therapeutic and preventive implications of current evidence. Am J Cardiovasc Drugs 6:87-101
Liu, Kiang; Dyer, Alan R; Vu, Thanh-Huyen et al. (2005) One-hour postload plasma glucose in middle age and Medicare expenditures in older age among nondiabetic men and women: the Chicago Heart Association Detection Project in Industry. Diabetes Care 28:1057-62
Daviglus, Martha L; Liu, Kiang; Pirzada, Amber et al. (2005) Relationship of fruit and vegetable consumption in middle-aged men to medicare expenditures in older age: the Chicago Western Electric Study. J Am Diet Assoc 105:1735-44
Daviglus, Martha L; Liu, Kiang; Pirzada, Amber et al. (2005) Cardiovascular risk profile earlier in life and Medicare costs in the last year of life. Arch Intern Med 165:1028-34
Daviglus, Martha L; Liu, Kiang; Yan, Lijing L et al. (2004) Relation of body mass index in young adulthood and middle age to Medicare expenditures in older age. JAMA 292:2743-9
Yan, Lijing L; Daviglus, Martha L; Liu, Kiang et al. (2004) BMI and health-related quality of life in adults 65 years and older. Obes Res 12:69-76

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