The broad objective of this research is to develop magnetic resonance imaging (MRJ) techniques that will accurately detect significant lesions in the coronary arteries. MRI offers many advantages over CT and x- ray angiography for imaging coronary artery disease, including rich and adjustable contrasts between different tissues, noninvasive procedures, no use of ionizing radiation, and no risk of nephrotoxicity. Prior studies have demonstrated the feasibility of imaging both the coronary lumen and wall, but diagnostic accuracy is still impaired by motion artifacts. Coronary MR Angiography (MRA) technology is rapidly evolving. Studies in the prior funding cycle have led to several key findings. SSFP has been identified as the best sequence for coronary MRA because of its high SNR efficiency and fast imaging speed. Real time navigator gating provides higher spatial resolution and image quality than breath-holding for coronary MRA. There is still inconsistency in coronary MRA quality because of the use of electrocardiogram and the diaphragm navigator echo, neither of which directly measures coronary motion. We have recently developed the coronary fat navigator method that allows direct and accurate monitoring of coronary motion. Accordingly, we propose here to develop the coronary fat navigator for SSFP coronary MRA to achieve effective motion suppression. We have also developed a simultaneous multiple volume (SMV) algorithm for efficient navigator gating. Preliminary data demonstrate that the SMV algorithm shortens navigator gated scan time by 2-3 fold. Accordingly, we propose to incorporate SMV gating into navigator coronary MRA to shorten scan time. We have also obtained preliminary experience in imaging coronary vessel walls. The navigator technology can be directly employed to reduce motion blurring artifacts in high resolution plaque imaging, which would provide valuable information for characterizing atherosclerotic plaque in coronary arteries. This research consists of two specific aims: 1) develop an efficient and effective navigator method for imaging the coronary lumen and wall; and 2) evaluate the developed coronary MRI in patients with coronary artery disease by comparing to conventional x-ray angiography and intravascular ultrasound. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL062994-06A2
Application #
7095717
Study Section
Special Emphasis Panel (ZRG1-SBIB-S (02))
Program Officer
Evans, Frank
Project Start
2000-09-30
Project End
2011-05-31
Budget Start
2006-08-01
Budget End
2007-05-31
Support Year
6
Fiscal Year
2006
Total Cost
$403,000
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Liu, Jing; Nguyen, Thanh D; Zhu, Yanchun et al. (2014) Self-gated free-breathing 3D coronary CINE imaging with simultaneous water and fat visualization. PLoS One 9:e89315
Cooper, Mitchell A; Nguyen, Thanh D; Spincemaille, Pascal et al. (2012) Flip angle profile correction for T? and T? quantification with look-locker inversion recovery 2D steady-state free precession imaging. Magn Reson Med 68:1579-85
Liu, Tian; Khalidov, Ildar; de Rochefort, Ludovic et al. (2011) A novel background field removal method for MRI using projection onto dipole fields (PDF). NMR Biomed 24:1129-36
Singh, Gurmeet; Raj, Ashish; Kressler, Bryan et al. (2011) A fast Edge-preserving Bayesian reconstruction method for Parallel Imaging applications in cardiac MRI. Magn Reson Med 65:184-9
Spincemaille, Pascal; Liu, Jing; Nguyen, Thanh et al. (2011) Z intensity-weighted position self-respiratory gating method for free-breathing 3D cardiac CINE imaging. Magn Reson Imaging 29:861-8
Codella, Noel C F; Spincemaille, Pascal; Prince, Martin et al. (2011) A radial self-calibrated (RASCAL) generalized autocalibrating partially parallel acquisition (GRAPPA) method using weight interpolation. NMR Biomed 24:844-54
Brown, Ryan; Nguyen, Thanh D; Spincemaille, Pascal et al. (2010) Effect of blood flow on double inversion recovery vessel wall MRI of the peripheral arteries: quantitation with T2 mapping and comparison with flow-insensitive T2-prepared inversion recovery imaging. Magn Reson Med 63:736-44
Kressler, Bryan; de Rochefort, Ludovic; Liu, Tian et al. (2010) Nonlinear regularization for per voxel estimation of magnetic susceptibility distributions from MRI field maps. IEEE Trans Med Imaging 29:273-81
Nguyen, Thanh D; Spincemaille, Pascal; Cham, Matthew D et al. (2009) Free-breathing 3-dimensional steady-state free precession coronary magnetic resonance angiography: comparison of four navigator gating techniques. Magn Reson Imaging 27:807-14
Nguyen, Thanh D; Spincemaille, Pascal; Cham, Matthew D et al. (2008) Free-breathing 3D steady-state free precession coronary magnetic resonance angiography: comparison of diaphragm and cardiac fat navigators. J Magn Reson Imaging 28:509-14

Showing the most recent 10 out of 25 publications